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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Buzaleh A M, Enriquez de Salamanca R, Batlle A M

Centro de Investigaciones sobre Porfirinas v Porifirias (CIPYP), (CONICET-FCEN, UBA), Ciudad Universitaria, Buenos Aires, Argentine.

Gen Pharmacol. 1992 Jul;23(4):665-9. doi: 10.1016/0306-3623(92)90145-a.

The effect of enflurane, a volatile anesthetic, on heme metabolism was studied. Different doses (0.5-6.0 ml/kg) of this anesthetic were administered i.p. to mice and animals sacrificed at different times after administration (5-240 min). 2. The dose of 2 ml/kg was chosen as the optimum anesthetic dose producing more alterations in the heme pathway. 3. ALA-S was significantly induced at earlier times of anesthesia. 4. Blood PBGase and deaminase was greatly reduced. 5. This diminution coupled with ALA-S induction are in accordance with the known biochemical changes occurring in acute intermittent porphyria and include enflurane in the list of porphyrinogenic drugs, the use of which is not recommended for the management of anesthesia in porphyric patients.

研究了挥发性麻醉剂恩氟烷对血红素代谢的影响。将不同剂量（0.5 - 6.0毫升/千克）的这种麻醉剂腹腔注射给小鼠，并在给药后不同时间（5 - 240分钟）处死动物。2. 选择2毫升/千克的剂量作为在血红素途径中产生更多变化的最佳麻醉剂量。3. 在麻醉早期，ALA - S被显著诱导。4. 血液中的PBGase和脱氨酶大幅降低。5. 这种降低与ALA - S的诱导与急性间歇性卟啉症中已知的生化变化一致，并且将恩氟烷列入致卟啉药物名单，不建议使用其对卟啉症患者进行麻醉管理。

Buzaleh A M, Enriquez de Salamanca R, Batlle A M

Centro de Investigaciones sobre Porfirinas v Porifirias (CIPYP), (CONICET-FCEN, UBA), Ciudad Universitaria, Buenos Aires, Argentine.

Gen Pharmacol. 1992 Jul;23(4):665-9. doi: 10.1016/0306-3623(92)90145-a.

The effect of enflurane, a volatile anesthetic, on heme metabolism was studied. Different doses (0.5-6.0 ml/kg) of this anesthetic were administered i.p. to mice and animals sacrificed at different times after administration (5-240 min). 2. The dose of 2 ml/kg was chosen as the optimum anesthetic dose producing more alterations in the heme pathway. 3. ALA-S was significantly induced at earlier times of anesthesia. 4. Blood PBGase and deaminase was greatly reduced. 5. This diminution coupled with ALA-S induction are in accordance with the known biochemical changes occurring in acute intermittent porphyria and include enflurane in the list of porphyrinogenic drugs, the use of which is not recommended for the management of anesthesia in porphyric patients.

研究了挥发性麻醉剂恩氟烷对血红素代谢的影响。将不同剂量（0.5 - 6.0毫升/千克）的这种麻醉剂腹腔注射给小鼠，并在给药后不同时间（5 - 240分钟）处死动物。2. 选择2毫升/千克的剂量作为在血红素途径中产生更多变化的最佳麻醉剂量。3. 在麻醉早期，ALA - S被显著诱导。4. 血液中的PBGase和脱氨酶大幅降低。5. 这种降低与ALA - S的诱导与急性间歇性卟啉症中已知的生化变化一致，并且将恩氟烷列入致卟啉药物名单，不建议使用其对卟啉症患者进行麻醉管理。