Corel L J, Van den Broeck J, Rongen-Westerlaken C, Massa G, Wit J M
Bureau of the Dutch Growth Foundation, University Hospital Leiden, the Netherlands.
Int J Obes Relat Metab Disord. 1996 Oct;20(10):957-62.
As overweight is a major concern in many children with Turner syndrome, we studied the effect of growth-promoting treatment with human growth hormone (hGH) on body weight indices.
Longitudinal study of the effect of hGH on weight indices over time in a cohort of Turner girls of different ages.
An index group of 199 hGH treated girls and a reference group of 569 untreated girls.
Turner-specific weight-for-age, weight-for-height and body mass index-for-age (BMI) values were computed. In order to take account of regression to the mean, we studied spontaneous changes of these variables in the reference group. References for spontaneous changes over 3, 6, 12 or 24 months were constructed. Observed changes in the index group were corrected by subtracting the expected spontaneous change. Corrected changes were compared between overweight, normal and underweight children.
Treatment with hGH leads to a temporary decrease of weight indices during the first six months. This decreasing effect was not seen in overweight children. Treatment increases BMI in overweight children over 24 months, but not in normal or underweight children. BMI at start of hGH treatment did not modify long-term growth response.
hGH treatment does not help to improve BMI in Turner syndrome children with a tendency to overweight.
由于超重是许多特纳综合征患儿的主要问题，我们研究了使用人生长激素（hGH）进行促生长治疗对体重指数的影响。
对不同年龄的特纳综合征女孩队列中hGH对体重指数随时间的影响进行纵向研究。
199名接受hGH治疗的女孩作为指数组，569名未接受治疗的女孩作为参照组。
计算特纳综合征特定的年龄别体重、身高别体重和年龄别体质指数（BMI）值。为了考虑均值回归，我们研究了参照组中这些变量的自发变化。构建了3、6、12或24个月内自发变化的参考值。通过减去预期的自发变化来校正指数组中观察到的变化。对超重、正常体重和体重不足儿童的校正变化进行比较。
hGH治疗在最初六个月导致体重指数暂时下降。超重儿童未出现这种下降效应。治疗使超重儿童在24个月内BMI增加，但正常体重或体重不足儿童未增加。hGH治疗开始时的BMI并未改变长期生长反应。
hGH治疗无助于改善有超重倾向的特纳综合征患儿的BMI。
