Smith J R, Freije D, Carpten J D, Grönberg H, Xu J, Isaacs S D, Brownstein M J, Bova G S, Guo H, Bujnovszky P, Nusskern D R, Damber J E, Bergh A, Emanuelsson M, Kallioniemi O P, Walker-Daniels J, Bailey-Wilson J E, Beaty T H, Meyers D A, Walsh P C, Collins F S, Trent J M, Isaacs W B
National Center for Human Genome Research, National Institutes of Health, Bethesda, MD, USA.
Science. 1996 Nov 22;274(5291):1371-4. doi: 10.1126/science.274.5291.1371.
Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.
尽管前列腺癌的发病率很高，但关于前列腺癌的遗传易感性却知之甚少。对66个高危前列腺癌家族进行的全基因组扫描提供了与1号染色体长臂（1q24 - 25）连锁的证据。对另外25个北美和瑞典家族在该区域进行标记分析，结果在这91个家族的组合集中发现了显著的连锁证据。这些数据为1号染色体上存在一个主要的前列腺癌易感基因座提供了有力证据。
