Marcus S L, Winrow C J, Capone J P, Rachubinski R A
Department of Anatomy and Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
J Biol Chem. 1996 Nov 1;271(44):27197-200. doi: 10.1074/jbc.271.44.27197.
Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, COUP-TFII stimulates transcription directly. A cellular factor, isolated by interaction cloning, bound COUP-TFII in vitro and allowed COUP-TFII to function as a transcriptional activator in mammalian cells. This factor is identical to a recently described ligand of the tyrosine kinase signaling molecule p56(lck), suggesting that it mediates cross-talk between mitogenic and nuclear hormone receptor signal transduction pathways.
鸡卵清蛋白上游启动子转录因子II（COUP-TFII）是核激素受体超家族的一个孤儿成员，通过拮抗其他核激素受体的功能并积极沉默转录来发挥转录抑制因子的作用。然而，在某些情况下，COUP-TFII可直接刺激转录。通过相互作用克隆分离出一种细胞因子，它在体外与COUP-TFII结合，并使COUP-TFII在哺乳动物细胞中发挥转录激活因子的作用。该因子与酪氨酸激酶信号分子p56(lck)最近描述的一种配体相同，这表明它介导有丝分裂原和核激素受体信号转导途径之间的相互作用。
