文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Piepho R W, Friedman A H

Clin Exp Pharmacol Physiol. 1977 May-Jun;4(3):263-6. doi: 10.1111/j.1440-1681.1977.tb02623.x.

The response of individually caged mice to the lethal actions of allylglycine and strychnine was evaluated in animals previously conditioned on an LD 12:12 (12 h light-12 h darkness) schedule in a controlled environment. 2. These convulsant agents were most toxic at 18.00 hours (during the light phase), and least toxic in the dark phase of the programmed lighting schedule. The relationship is considered of the circadian fluctuations in levels of inhibitory transmitter substances to the time-linked action of convulsant agents.

在受控环境中，对先前按照12小时光照：12小时黑暗（LD 12:12）时间表进行条件设定的单独饲养的小鼠，评估其对烯丙基甘氨酸和士的宁致死作用的反应。2. 这些惊厥剂在18:00时（光照阶段）毒性最大，而在设定光照时间表的黑暗阶段毒性最小。这种关系被认为与抑制性递质物质水平的昼夜节律波动以及惊厥剂的时间关联作用有关。

Piepho R W, Friedman A H

Clin Exp Pharmacol Physiol. 1977 May-Jun;4(3):263-6. doi: 10.1111/j.1440-1681.1977.tb02623.x.

The response of individually caged mice to the lethal actions of allylglycine and strychnine was evaluated in animals previously conditioned on an LD 12:12 (12 h light-12 h darkness) schedule in a controlled environment. 2. These convulsant agents were most toxic at 18.00 hours (during the light phase), and least toxic in the dark phase of the programmed lighting schedule. The relationship is considered of the circadian fluctuations in levels of inhibitory transmitter substances to the time-linked action of convulsant agents.

在受控环境中，对先前按照12小时光照：12小时黑暗（LD 12:12）时间表进行条件设定的单独饲养的小鼠，评估其对烯丙基甘氨酸和士的宁致死作用的反应。2. 这些惊厥剂在18:00时（光照阶段）毒性最大，而在设定光照时间表的黑暗阶段毒性最小。这种关系被认为与抑制性递质物质水平的昼夜节律波动以及惊厥剂的时间关联作用有关。