Zacharias M, Hunter K M, Parkinson R
Department of Anaesthesia and Intensive Care, Dunedin School of Medicine, University of Otago, Dunedin.
N Z Dent J. 1996 Sep;92(409):76-9.
Thirty-four healthy, young-adult patients receiving intravenous midazolam for third-molar surgery had their respiratory parameters measured by respiratory inductive plethysmography. Tidal volume and minute volume showed significant changes during the initial 5-10 minutes of sedation, the changes being maximal during the first 5 minutes from the completion of injection of midazolam. The measurement of phase angle, an indicator of respiratory asynchrony, showed no significant change from normal, although a few patients showed some asynchrony of breathing, suggesting some amount of respiratory obstruction. A few patients showed a short period of apnoea and a small fall in the oxygen saturation. None of these changes caused any clinical concerns. It is suggested that the absence of stimulation after injection of midazolam, particularly in the initial few minutes, may contribute to the potential onset of respiratory problems.
34名接受静脉注射咪达唑仑进行第三磨牙手术的健康年轻成年患者，通过呼吸感应体积描记法测量其呼吸参数。潮气量和分钟通气量在镇静最初的5 - 10分钟内出现显著变化，这些变化在咪达唑仑注射完成后的前5分钟内最大。作为呼吸不同步指标的相角测量显示与正常情况无显著变化，尽管有少数患者出现了一些呼吸不同步，提示存在一定程度的呼吸道阻塞。少数患者出现了短时间的呼吸暂停和血氧饱和度小幅下降。这些变化均未引起任何临床担忧。有人认为，注射咪达唑仑后缺乏刺激，尤其是在最初几分钟，可能会导致呼吸问题的潜在发生。
