Saei A, Ward J, McGilchrist C A
National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.
Stat Med. 1996 Oct 30;15(20):2253-60. doi: 10.1002/(SICI)1097-0258(19961030)15:20<2253::AID-SIM368>3.0.CO;2-7.
The degree of non-compliance with a methadone programme is such that a zero is often recorded as the response variable. Such outcome variables cannot be transformed to normality in order to investigate a regression relationship between the response variable and various risk or treatment variables. The presence of a random effect as well in this regression causes added difficulty in the analysis. We show here that use of threshold models can provide a satisfactory solution to both these problems.
美沙酮治疗方案的不依从程度很高，以至于通常将零记录为响应变量。为了研究响应变量与各种风险或治疗变量之间的回归关系，无法将此类结果变量转换为正态分布。这种回归中随机效应的存在也给分析带来了额外的困难。我们在此表明，使用阈值模型可以为这两个问题提供令人满意的解决方案。
