Stomper P C, D'Souza D J, DiNitto P A, Arredondo M A
Division of Diagnostic Imaging, Roswell Park Cancer Institute, School of Medicine and Biomedical Sciences, State University of New York at Buffalo 14263, USA.
AJR Am J Roentgenol. 1996 Nov;167(5):1261-5. doi: 10.2214/ajr.167.5.8911192.
This study was undertaken to determine the frequency and distribution of dense mammograms. Factors that may affect parenchymal density of breasts among the diverse age groups of women who undergo mammography were also studied.
Mammograms of 1353 women between 25 and 79 years old who were grouped in 5-year age cohorts were reviewed. Breast density and the presence of benign calcifications were analyzed.
Parenchymal density on mammograms decreased progressively in the patient cohorts 25-29 years old through 75-79 years old (Spearman correlation, p < .01). In the cohort of 25- through 29-year-old patients, 38% had predominantly (> 50%) fatty breasts. In the cohort of 75- through 79-year-old patients, 76% had predominantly fatty breasts. Increased parenchymal density mammograms were more common in women who had smaller breasts, had had fewer than two pregnancies, and underwent hormone replacement (p < .01). Forty-nine percent of women 50-79 years old undergoing hormone replacement had predominantly dense breasts, a percentage similar to that (48%) of the patient cohort of women 40-44 years old. Prevalence of benign calcifications also increased with age, from 8% at ages 25-29 to 86% at ages 75-79 (p < .01).
In our study, a significant percentage (38%) of women who were 25-39 years old had predominantly fatty breast tissue that should not impede selective mammographic screening or diagnostic efforts in this age group.
本研究旨在确定致密型乳腺X线照片的频率和分布情况。同时还研究了在接受乳腺X线摄影检查的不同年龄组女性中，可能影响乳房实质密度的因素。
回顾了1353名年龄在25至79岁之间、按5岁年龄组划分的女性的乳腺X线照片。分析了乳房密度和良性钙化的情况。
在25 - 29岁至75 - 79岁的患者队列中，乳腺X线照片上的实质密度逐渐降低（Spearman相关性，p < .01）。在25至29岁的患者队列中，38%的女性乳房主要为（> 50%）脂肪型。在75至79岁的患者队列中，76%的女性乳房主要为脂肪型。乳房较小、怀孕次数少于两次且接受激素替代治疗的女性，乳腺X线照片上实质密度增加更为常见（p < .01）。在5至79岁接受激素替代治疗的女性中，49%的乳房主要为致密型，这一比例与40至44岁患者队列中的比例（48%）相似。良性钙化的患病率也随年龄增加，从25 - 29岁时的8%增至75 - 79岁时的86%（p < .01）。
在我们的研究中，25至39岁的女性中有相当比例（38%）的乳房主要为脂肪组织，这不应妨碍该年龄组进行选择性乳腺X线筛查或诊断工作。
