Karakiewicz P I, Aprikian A G, Meshref A W, Bazinet M
UROMED Prostate Cancer Detection Center, Montréal, Québec, Canada.
Urology. 1996 Nov;48(5):747-50. doi: 10.1016/S0090-4295(96)00230-0.
To assess the potential difference in positive biopsy rates between four-sector and six-sector biopsy methods.
This computer-assisted analysis is based on the records of 156 consecutive patients previously diagnosed with T1c cancer on systematic sextant biopsy of the peripheral zone. For each patient the computer randomly deleted one biopsy result from the left and right prostatic lobes. The deletion process was repeated 1000 times. Based on four randomly chosen biopsy cores, we determined the number of undetected cancers initially diagnosed with sextant biopsy.
Based on four-sector biopsy cores of the peripheral zone, between 6 and 30 (3.8% to 19.2% of cases) nonpalpable, isoechoic prostate cancers that were detected with sextant biopsy would have remained undiagnosed.
Our results suggest that the number of biopsy cores used in the early detection of nonpalpable, isoechoic prostate cancer may substantially affect the rate of positive findings.
评估四分区活检法与六分区活检法在阳性活检率方面的潜在差异。
本计算机辅助分析基于156例先前经外周区系统性六分区活检诊断为T1c期癌症的连续患者的记录。对于每位患者，计算机随机从前列腺左右叶中删除一个活检结果。该删除过程重复1000次。基于随机选择的四个活检样本，我们确定了最初经六分区活检诊断出的未被检测到的癌症数量。
基于外周区的四分区活检样本，六分区活检检测到的6至30例（占病例的3.8%至19.2%）不可触及的等回声前列腺癌本应仍未被诊断出来。
我们的结果表明，在不可触及的等回声前列腺癌早期检测中使用的活检样本数量可能会显著影响阳性结果率。
