Jorgensen C, Sany J
Immuno-Rheumatology Department, Lapeyronie Hospital, Montpellier, France.
Baillieres Clin Rheumatol. 1996 May;10(2):379-92. doi: 10.1016/s0950-3579(96)80023-9.
Modulation of the immune network through the hormonal system is an exciting emerging concept. It results from a decade of experimental research obtained on rodents. Unfortunately, the therapeutic response on NZB/NZW F1 mice with murine lupus or in adjuvant induced arthritis are not transferable to man. This new field opens new therapeutic perspectives with well known and relatively safe drugs (hormone agonists, antagonists or inhibitors of hormonal secretion). Today we lack controlled, randomized clinical studies, with long-term follow-up. We also need to identify the subgroup of patients who could benefit from hormonal immunomodulation (sex, basal hormonal status, menopausal status for women, disease activity).
通过激素系统调节免疫网络是一个令人兴奋的新兴概念。它源于对啮齿动物进行的十年实验研究。不幸的是，对患有鼠类狼疮的NZB/NZW F1小鼠或佐剂诱导性关节炎的治疗反应无法应用于人类。这个新领域为使用知名且相对安全的药物（激素激动剂、拮抗剂或激素分泌抑制剂）开辟了新的治疗前景。如今，我们缺乏长期随访的对照、随机临床研究。我们还需要确定能够从激素免疫调节中获益的患者亚组（性别、基础激素状态、女性的绝经状态、疾病活动度）。
