Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 710032, Shaanxi Province, People's Republic of China.
Curr Rheumatol Rep. 2018 Apr 16;20(5):30. doi: 10.1007/s11926-018-0729-1.
This study aims to review the advances of Treg cell biology, the functional defects of Treg cells, and the potential strategies for the experimental, preclinical or clinical application of Treg cell therapy in the context of autoimmune/immune-mediated rheumatic diseases.
CD4CD25 regulatory T (Treg) cells are a phenotypically and functionally heterogeneous subset of lymphocytes that prevent a variety of autoimmune diseases. As in many autoimmune diseases, the functional defects of Treg cells are supposed to play relevant roles in the pathogenesis and development of systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, and other autoimmune/immune-mediated rheumatic diseases. Consequently, manipulation and modulation of Treg cells represent a potent strategy for therapeutic benefit in many such diseases. A further understanding of the functional defects of Treg cells in rheumatic diseases will contribute to find new targets and therapies in rheumatic diseases, including ankylosing spondylitis.
本研究旨在综述调节性 T（Treg）细胞生物学的进展、Treg 细胞的功能缺陷，以及 Treg 细胞治疗在自身免疫/免疫介导性风湿性疾病中的实验、临床前或临床应用的潜在策略。
CD4CD25 调节性 T（Treg）细胞是淋巴细胞中表型和功能具有异质性的亚群，可预防多种自身免疫性疾病。在许多自身免疫性疾病中，Treg 细胞的功能缺陷被认为与系统性红斑狼疮、类风湿关节炎、强直性脊柱炎和其他自身免疫/免疫介导性风湿性疾病的发病机制和发展有关。因此，Treg 细胞的操纵和调节代表了许多此类疾病治疗获益的一种有效策略。进一步了解风湿性疾病中 Treg 细胞的功能缺陷将有助于找到风湿性疾病（包括强直性脊柱炎）的新靶点和治疗方法。
