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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

McConalogue K, Todorov L, Furness J B, Westfall D P

Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1996 Sep;23(9):807-12. doi: 10.1111/j.1440-1681.1996.tb01184.x.

The release of adenosine triphosphate (ATP), adenosine diphosphate, adenosine monophosphate and adenosine from guinea-pig taenia coli in response to electrical stimulation of intramural nerves was measured directly using high performance liquid chromatography separation and fluorometric detection. 2. Purines were released in a frequency-dependent manner by trains of transmural electrical pulses at 1-30 Hz. 3. Electrically evoked release of ATP was abolished by tetrodotoxin (10(-6)mol/L) but was not affected by nicardipine (10(-6)mol/L). 4. The release of purines was reduced in the presence of atropine. 5. Pituitary adenylyl cyclase-activating peptide did not evoke the release of any purines and did not modify the electrically evoked release of purines. 6. The results suggest that ATP and its major metabolites are released from a neuronal source, possibly the enteric inhibitory nerves, in the guinea-pig taenia coli.

使用高效液相色谱分离和荧光检测法，直接测定了豚鼠结肠带在对壁内神经进行电刺激时三磷酸腺苷（ATP）、二磷酸腺苷、一磷酸腺苷和腺苷的释放量。2. 在1 - 30Hz的跨壁电脉冲串刺激下，嘌呤以频率依赖性方式释放。3. 河豚毒素（10⁻⁶mol/L）可消除电诱发的ATP释放，但尼卡地平（10⁻⁶mol/L）对其无影响。4. 阿托品存在时，嘌呤的释放减少。5. 垂体腺苷酸环化酶激活肽不会诱发任何嘌呤的释放，也不会改变电诱发的嘌呤释放。6. 结果表明，在豚鼠结肠带中，ATP及其主要代谢产物从神经元来源释放，可能是肠抑制性神经。

McConalogue K, Todorov L, Furness J B, Westfall D P

Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1996 Sep;23(9):807-12. doi: 10.1111/j.1440-1681.1996.tb01184.x.

The release of adenosine triphosphate (ATP), adenosine diphosphate, adenosine monophosphate and adenosine from guinea-pig taenia coli in response to electrical stimulation of intramural nerves was measured directly using high performance liquid chromatography separation and fluorometric detection. 2. Purines were released in a frequency-dependent manner by trains of transmural electrical pulses at 1-30 Hz. 3. Electrically evoked release of ATP was abolished by tetrodotoxin (10(-6)mol/L) but was not affected by nicardipine (10(-6)mol/L). 4. The release of purines was reduced in the presence of atropine. 5. Pituitary adenylyl cyclase-activating peptide did not evoke the release of any purines and did not modify the electrically evoked release of purines. 6. The results suggest that ATP and its major metabolites are released from a neuronal source, possibly the enteric inhibitory nerves, in the guinea-pig taenia coli.

使用高效液相色谱分离和荧光检测法，直接测定了豚鼠结肠带在对壁内神经进行电刺激时三磷酸腺苷（ATP）、二磷酸腺苷、一磷酸腺苷和腺苷的释放量。2. 在1 - 30Hz的跨壁电脉冲串刺激下，嘌呤以频率依赖性方式释放。3. 河豚毒素（10⁻⁶mol/L）可消除电诱发的ATP释放，但尼卡地平（10⁻⁶mol/L）对其无影响。4. 阿托品存在时，嘌呤的释放减少。5. 垂体腺苷酸环化酶激活肽不会诱发任何嘌呤的释放，也不会改变电诱发的嘌呤释放。6. 结果表明，在豚鼠结肠带中，ATP及其主要代谢产物从神经元来源释放，可能是肠抑制性神经。