Gerich J E
University of Rochester, Medical Center, New York, USA.
Horm Metab Res. 1996 Sep;28(9):404-12. doi: 10.1055/s-2007-979828.
Noninsulin-dependent diabetes mellitus is a major health problem affecting nearly 100,000,000 million people world-wide. Its pathogenesis is multifactorial involving both genetic (e.g. impaired insulin-secretion) and acquired (e.g. insulin-resistance) factors which cause overproduction of glucose and inefficient glucose utilization. The cost and suffering from this disease are primarily due to its longterm complications which controlled clinical trials indicate can be prevented with good glycemic control. However most patients are currently not under satisfactory control. More intensive efforts with judicious combinations of presently available modalities by specialists having educational and motivational support teams and the expected introduction of new therapeutic agents should make it possible for most patients to achieve levels of glycemic control which will prevent their developing complications.
非胰岛素依赖型糖尿病是一个重大的健康问题，全球近1亿人受其影响。其发病机制是多因素的，涉及遗传（如胰岛素分泌受损）和后天（如胰岛素抵抗）因素，这些因素导致葡萄糖过度产生和葡萄糖利用效率低下。这种疾病的代价和痛苦主要归因于其长期并发症，对照临床试验表明，良好的血糖控制可以预防这些并发症。然而，目前大多数患者的病情并未得到令人满意的控制。通过配备教育和激励支持团队的专家明智地组合目前可用的治疗方法，并预期引入新的治疗药物，加大力度，应能使大多数患者实现血糖控制水平，从而预防并发症的发生。
