Bredal W P, Gunnes G, Vollset I, Ulstein T L
Department of Small Animal Clinical Sciences, Norwegian College of Veterinary Medicine, Oslo, Norway.
J Small Anim Pract. 1996 Oct;37(10):499-504. doi: 10.1111/j.1748-5827.1996.tb01753.x.
Oral eosinophilic granuloma is a rare and enigmatic disease in dogs. The clinical, haematological, cytological and histopathological features of three unrelated Cavalier King Charles spaniels with oral ulcers are presented. The disease was characterised by granuloma or plaque formation in the oral cavity. Common clinical signs were clearing the throat, swallowing problems, coughing during and after meals, reduced appetite and difficulty in eating. Haematological findings were not specific. Cytology was considered easier to perform than tissue biopsy due to friability of the tissue, but could not be used to confirm a granuloma diagnosis. The diagnosis of oral eosinophilic granuloma was verified histopathologically in each case. Response to glucocorticoid therapy varied, from complete remission to lack of any visible effect, leading to a guarded prognosis. The aetiology of the disease was not determined; however, the gross and microscopic morphologies of the lesions, their location and the response to corticosteroid therapy was suggestive of hypersensitivity.
口腔嗜酸性肉芽肿在犬类中是一种罕见且神秘的疾病。本文介绍了三只无亲缘关系的患有口腔溃疡的骑士查理王小猎犬的临床、血液学、细胞学和组织病理学特征。该疾病的特征是口腔内形成肉芽肿或斑块。常见的临床症状包括清嗓、吞咽困难、进食期间及之后咳嗽、食欲减退和进食困难。血液学检查结果不具有特异性。由于组织易碎，细胞学检查被认为比组织活检更容易进行，但无法用于确诊肉芽肿。每例均经组织病理学证实为口腔嗜酸性肉芽肿。糖皮质激素治疗的反应各不相同，从完全缓解到无任何明显效果，预后谨慎。该疾病的病因尚未确定；然而，病变的大体和微观形态、位置以及对皮质类固醇治疗的反应提示为超敏反应。
