Gupta R K, Simpson J, Dowle C
Department of Laboratory Services, Wellington Hospital and School of Medicine, New Zealand.
Pathology. 1996 Aug;28(3):248-50. doi: 10.1080/00313029600169084.
Although rare, eczematous skin changes ascribed to Paget's disease of the nipple nevertheless warrant timely diagnosis. However this may occasionally be delayed due to a reluctance to proceed to traditional diagnostic techniques of wedge biopsy, surgical excision or punch biopsy. In this communication we describe 11 cases of unilateral mammary Paget's disease, in which an unequivocal cytodiagnosis was made from nipple scrapings. In five of these cases an underlying ductal carcinoma of the breast was simultaneously diagnosed by fine needle aspiration (FNA) cytology of a palpable breast lump. All 11 cases were subsequently proven histologically to be Paget's disease. Despite the fact that the use in dermatology of scrape smears and fine needle aspiration cytology remains somewhat unpopular, it is suggested that the screening of any eczematous skin change of the nipple should be considered using the simple, reliable and non-invasive technique of scrape cytology.
尽管罕见，但归因于乳头佩吉特病的湿疹样皮肤改变仍需及时诊断。然而，由于不愿采用楔形活检、手术切除或打孔活检等传统诊断技术，诊断有时可能会延迟。在本报告中，我们描述了11例单侧乳腺佩吉特病病例，其中通过乳头刮片做出了明确的细胞诊断。在其中5例病例中，通过对可触及乳腺肿块的细针穿刺（FNA）细胞学检查同时诊断出了潜在的乳腺导管癌。所有11例病例随后经组织学证实为佩吉特病。尽管刮片涂片和细针穿刺细胞学检查在皮肤科的应用仍不太受欢迎，但建议应考虑使用简单、可靠且无创的刮片细胞学技术对乳头的任何湿疹样皮肤改变进行筛查。
