Shi X B, Gumerlock P H, deVere White R W
Department of Urology, University of California, Davis, Sacramento 95817, USA.
World J Urol. 1996;14(5):318-28. doi: 10.1007/BF00184605.
Carcinoma of the prostate (CaP) is a very prevalent tumor among men. However thus far, relatively little information is known about the molecular mechanisms involved in the development, progression and metastasis of this disease. This article reviews the current state of knowledge of five selected molecular aspects of human CaP: tumor suppressor genes, metastasis suppressor genes and related biological events (allelic loss and DNA methylation), oncogenes (including growth factors and their receptors), the anti-apoptosis gene BCL2, and the human androgen receptor gene (hAR). Alterations of these genes in structure and expression as well as the frequencies of these molecular events are discussed to synthesize an understanding of documented genetic alterations that occur in CaP and their possible relation to the biology of the disease.
前列腺癌（CaP）是男性中非常常见的肿瘤。然而，迄今为止，关于这种疾病发生、发展和转移所涉及的分子机制，我们所知相对较少。本文综述了人类CaP五个选定分子方面的当前知识状态：肿瘤抑制基因、转移抑制基因及相关生物学事件（等位基因缺失和DNA甲基化）、癌基因（包括生长因子及其受体）、抗凋亡基因BCL2以及人类雄激素受体基因（hAR）。讨论了这些基因在结构和表达上的改变以及这些分子事件的频率，以综合理解CaP中已记录的基因改变及其与该疾病生物学的可能关系。
