de Berker D A, Taylor A E, Quinn A G, Simpson N B
Department of Dermatology, Royal Victoria Infirmary, UK.
J Am Acad Dermatol. 1996 Nov;35(5 Pt 1):696-9. doi: 10.1016/s0190-9622(96)90723-9.
Patients receiving kidney or heart transplants are subject to a wide range of cutaneous changes attributed largely to the immunosuppression required to prevent rejection of their transplant. In addition to infection, they have an increased incidence of dysplastic lesions, some of which are malignant.
Our purpose was to determine the incidence of sebaceous hyperplasia in heart and kidney transplant recipients and its association with neoplasia.
Patients undergoing heart transplantation from a single transplant center were examined during a 30-month screening period to establish the prevalence of cutaneous abnormalities.
Sixteen of 104 (16%) heart transplant recipients had sebaceous hyperplasia in comparison with 1% of an age- and sex-matched control group. Those with sebaceous hyperplasia did not have a significantly higher incidence of hypertrichosis than those without sebaceous hyperplasia.
Sebaceous hyperplasia is seen in heart transplant recipients. It does not appear to be connected with hypertrichosis, in which it is believed that the pilosebaceous unit is the target of the direct effect of cyclosporine. We propose that the development of sebaceous hyperplasia is related to the process of dysplastic epithelial proliferation in transplant recipients.
接受肾脏或心脏移植的患者会出现多种皮肤变化，这主要归因于预防移植排斥所需的免疫抑制。除感染外，他们发育异常性病变的发生率增加，其中一些是恶性的。
我们的目的是确定心脏和肾脏移植受者中皮脂腺增生的发生率及其与肿瘤形成的关联。
在一个30个月的筛查期内，对来自单一移植中心接受心脏移植的患者进行检查，以确定皮肤异常的患病率。
104名心脏移植受者中有16名（16%）出现皮脂腺增生，而年龄和性别匹配的对照组中这一比例为1%。有皮脂腺增生的患者毛发过多的发生率并不比没有皮脂腺增生的患者显著更高。
心脏移植受者中可见皮脂腺增生。它似乎与毛发过多无关，人们认为皮脂腺单位是环孢素直接作用的靶点。我们提出皮脂腺增生的发生与移植受者发育异常的上皮增殖过程有关。
