Euvrard S, Kanitakis J, Pouteil-Noble C, Dureau G, Touraine J L, Faure M, Claudy A, Thivolet J
Department of Dermatology, Ed. Herriot Hospital, Lyon, France.
J Am Acad Dermatol. 1995 Aug;33(2 Pt 1):222-9. doi: 10.1016/0190-9622(95)90239-2.
Cutaneous carcinomas are the most frequent cancers in organ transplant recipients.
Our purpose was to compare the epidemiologic data of cutaneous premalignant and malignant epithelial lesions in kidney and heart transplant recipients.
A total of 580 kidney and 150 heart transplant recipients were examined for the presence of premalignant and malignant epithelial lesions.
A twofold increase in incidence of premalignant and malignant epithelial lesions was found in heart compared with kidney transplant recipients. Heart transplant recipients were older at transplantation, received more intense immunosuppressive treatment, and had a shorter delay from transplantation to the development of the first lesion. The squamous cell carcinoma/basal cell carcinoma ratio was 2.37:1 in kidney and 1.08:1 in heart transplant recipients. The extracephalic location represented 60% of the premalignant and malignant epithelial lesions in kidney and 30% in heart transplant recipients.
Cutaneous premalignant and malignant epithelial lesions in kidney and heart transplant recipients show epidemiologic differences that can tentatively be explained by the older age and the more intense immunosuppressive treatment of heart transplant recipients.
皮肤癌是器官移植受者中最常见的癌症。
我们的目的是比较肾移植和心脏移植受者皮肤癌前和恶性上皮病变的流行病学数据。
对总共580名肾移植受者和150名心脏移植受者进行了癌前和恶性上皮病变检查。
与肾移植受者相比，心脏移植受者的癌前和恶性上皮病变发病率增加了两倍。心脏移植受者移植时年龄更大，接受的免疫抑制治疗更强，从移植到出现首个病变的间隔时间更短。肾移植受者的鳞状细胞癌/基底细胞癌比例为2.37:1，心脏移植受者为1.08:1。肾移植受者的癌前和恶性上皮病变60%位于头部以外，心脏移植受者为30%。
肾移植和心脏移植受者的皮肤癌前和恶性上皮病变存在流行病学差异，这可能初步解释为心脏移植受者年龄较大且免疫抑制治疗更强。
