Bodner S M, Koss M N
Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hum Pathol. 1996 Nov;27(11):1117-23. doi: 10.1016/s0046-8177(96)90302-0.
Well-differentiated fetal adenocarcinomas and biphasic blastomas are types of lung cancer that contain glands that mimic the appearance of fetal lung. Biphasic blastomas also show a primitive embryonic stroma. Despite histological similarities leading these two tumors to be classified as pulmonary blastomas, they have distinct clinical and prognostic features. Little information is available on genetic changes in these tumors because they are rare; therefore, the authors studied nine biphasic blastomas and 12 well-differentiated fetal adenocarcinomas for the presence of mutations in the p53 gene. Mutations in the p53 gene are common in other lung cancers, and the type of mutation in the p53 gene can provide information about the original or inciting mutagens. The authors found five biphasic blastomas (42%) had mutations in the p53 gene by immunohistochemical and molecular analysis, whereas none of the well-differentiated fetal adenocarcinomas contained mutations. These results provide molecular support for the significance of distinguishing between well-differentiated fetal adenocarcinoma and biphasic blastoma histologically and identify several types of p53 gene mutations that occur in these tumors.
高分化胎儿腺癌和双相母细胞瘤是肺癌的类型，其包含模仿胎儿肺外观的腺体。双相母细胞瘤还显示出原始的胚胎间质。尽管组织学上的相似性导致这两种肿瘤被归类为肺母细胞瘤，但它们具有不同的临床和预后特征。由于这些肿瘤罕见，关于其基因变化的信息很少；因此，作者研究了9例双相母细胞瘤和12例高分化胎儿腺癌中p53基因的突变情况。p53基因突变在其他肺癌中很常见，p53基因的突变类型可以提供有关原始或诱发诱变剂的信息。作者通过免疫组织化学和分子分析发现，5例双相母细胞瘤（42%）存在p53基因突变，而高分化胎儿腺癌均未发现突变。这些结果为从组织学上区分高分化胎儿腺癌和双相母细胞瘤的重要性提供了分子支持，并确定了这些肿瘤中发生的几种p53基因突变类型。
