某些含黄酮类化合物药用植物的体外细胞毒性作用

In vitro cytotoxic effect of some medicinal plants containing flavonoids.

作者信息

Trovato A, Monforte M T, Rossitto A, Forestieri A M

机构信息

Pharmaco-Biological Department, School of Pharmacy, Messina, Italy.

出版信息

Boll Chim Farm. 1996 Apr;135(4):263-6.

PMID:8913055

Abstract

Aqueous, ethanolic and petroleum ether extracts of Citrus sinensis L. (Osbeck), Euphrasia officinalis L., Glycyrrhiza glabra L., Matricaria recutita L., Rosa canina L. and Ruta graveolens L. have been studied. The cytotoxicity of the drugs assayed was evaluated "in vitro" by means of the dye test using cells of the Yoshida ascites sarcoma. The aqueous extract of Citrus sinensis L. (Osbeck); the petroleum ether extract of Glycyrrhiza glabra L.; the ethanolic and petroleum ether extracts of Rosa canina L. and the petroleum ether extract of Ruta graveolens L. showed a quite significative cytotoxic effect.

摘要

对甜橙（Citrus sinensis L. (Osbeck)）、小米草（Euphrasia officinalis L.）、光果甘草（Glycyrrhiza glabra L.）、母菊（Matricaria recutita L.）、犬蔷薇（Rosa canina L.）和芸香（Ruta graveolens L.）的水提取物、乙醇提取物和石油醚提取物进行了研究。通过使用吉田腹水肉瘤细胞的染料试验“体外”评估所测定药物的细胞毒性。甜橙（Citrus sinensis L. (Osbeck)）的水提取物；光果甘草（Glycyrrhiza glabra L.）的石油醚提取物；犬蔷薇（Rosa canina L.）的乙醇提取物和石油醚提取物以及芸香（Ruta graveolens L.）的石油醚提取物显示出相当显著的细胞毒性作用。