Watanabe K, Suzuki J, Suzuki H
Department of Pediatrics, Fukushima Medical College, Japan.
Nihon Jinzo Gakkai Shi. 1996 Sep;38(9):393-8.
To clarify the changes in the intracellular signal transduction system in the kidneys of aminonucleoside (AN)-induced nephrotic rats and the effect of steroid on these changes, we investigated the urinary protein excretion and PGE2 excretion with and without steroid administration as well as the metabolic turnover system of phosphatidylinositol (PI), which is one of the intracellular signal transduction systems mediated by the PGE2 receptor of the glomerulus isolated from the kidney. The following results were obtained: (10 The action of steroid in inhibiting proteinuria was not correlated with its action in inhibiting PGE2 production. (2) Enhanced PI turnover of the glomerulus isolated from the kidney was observed in the state of nephrosis. (3) Sensitivity of the PI turnover system to PGE2 was changed both in the state of nephrosis and after the disappearance of proteinuria, indicating the possible action of steroid in modifying the change. From the above, it was suggested that change in the PI turnover system of the glomerulus isolated from the kidney is deeply involved in the onset and recurrence of nephrosis.
为阐明氨基核苷（AN）诱导的肾病大鼠肾脏细胞内信号转导系统的变化以及类固醇对这些变化的影响，我们研究了给予和未给予类固醇时的尿蛋白排泄和PGE2排泄，以及磷脂酰肌醇（PI）的代谢周转系统，PI是由从肾脏分离的肾小球PGE2受体介导的细胞内信号转导系统之一。获得了以下结果：（1）类固醇抑制蛋白尿的作用与其抑制PGE2产生的作用不相关。（2）在肾病状态下观察到从肾脏分离的肾小球PI周转增强。（3）在肾病状态和蛋白尿消失后，PI周转系统对PGE2的敏感性均发生了变化，表明类固醇可能具有改变这种变化的作用。综上所述，提示从肾脏分离的肾小球PI周转系统的变化与肾病的发生和复发密切相关。
