一项关于门诊血液稀释治疗视网膜中央静脉阻塞的随机前瞻性研究。
A randomised prospective study of outpatient haemodilution for central retinal vein obstruction.
作者信息
Luckie A P, Wroblewski J J, Hamilton P, Bird A C, Sanders M, Slater N, Green W
机构信息
Moorfields Eye Hospital, London.
出版信息
Aust N Z J Ophthalmol. 1996 Aug;24(3):223-32. doi: 10.1111/j.1442-9071.1996.tb01584.x.
PURPOSE
Central retinal vein obstruction (CRVO) has significant visual morbidity. We prospectively evaluated an outpatient haemodilution (HD) regimen for CRVO.
METHODS
We recruited 59 patients with CRVO of less than three months' duration and visual acuity (VA) worse than or equal to 6/9.5. Thirty patients underwent HD (packed cell volume of <0.35, 12 weeks); there were 29 controls and follow-up was for six months.
RESULTS
Incidence rates for VA improvement (P = 0.708) and rubeosis iridis (P = 0.619) between the two groups were not different. The incidence rate of VA deterioration was 5.315 times higher with HD (P = 0.035, Cox Proportional analysis).
CONCLUSION
This data does not support the previous studies on haemodilution.
目的
视网膜中央静脉阻塞（CRVO）会导致严重的视力损害。我们前瞻性地评估了一种针对CRVO的门诊血液稀释（HD）方案。
方法
我们招募了59例病程少于三个月且视力（VA）小于或等于6/9.5的CRVO患者。30例患者接受血液稀释（血细胞比容<0.35，为期12周）；29例为对照组，随访6个月。
结果
两组之间视力改善发生率（P = 0.708）和虹膜红变发生率（P = 0.619）无差异。血液稀释组视力恶化发生率高5.315倍（P = 0.035，Cox比例分析）。
结论
这些数据不支持先前关于血液稀释的研究。
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