Osterman K, Osterman H
Orton Research Institute, Invalid Foundation, Helsinki, Finland.
Clin Orthop Relat Res. 1996 Nov(332):274-80.
Lumbosacral spondylolisthesis was provoked experimentally in growing rabbits by means of a bilateral facet joint resection at the L7-S1 segment. The effects of additional immobilization of the L6-L7 segment with bone cement and of severing the lumbosacral disc on the development of the olisthesis were tested. A mean ventral slip of 21% was seen after the facet joint resection. The slip resembled the spondylolisthesis seen in humans in wedging of the olisthetic vertebra, sacral rounding, and increased sagittal rotation. Combining the facet joint resection with immobilization of the L6-L7 segment resulted in a mean slip of 15%. Morphologic features of the slip were like those seen after a plain facet joint resection. A different result was seen after facet joint resection was combined with severing of the lumbosacral disc. The mean slip was only 6%, and sacral rounding was a prominent feature. This experiment shows that an upright posture of the spine is not a prerequisite for the development of spondylolisthesis. A bilateral facet joint resection in a growing rabbit results in a human like spondylolisthesis. This model may help further experimental studies concerning the changes in the olisthetic disc.
通过在L7 - S1节段进行双侧小关节切除术，在生长中的兔子身上实验性诱发腰骶部椎体滑脱。测试了用骨水泥额外固定L6 - L7节段以及切断腰骶椎间盘对椎体滑脱发展的影响。小关节切除术后可见平均21%的腹侧移位。该移位在滑脱椎体楔形变、骶骨圆钝以及矢状面旋转增加方面类似于人类所见的椎体滑脱。将小关节切除术与L6 - L7节段固定相结合导致平均移位为15%。移位的形态学特征与单纯小关节切除术后所见相似。小关节切除术与切断腰骶椎间盘相结合后出现了不同的结果。平均移位仅为6%，且骶骨圆钝是一个突出特征。该实验表明脊柱的直立姿势不是椎体滑脱发展的先决条件。在生长中的兔子身上进行双侧小关节切除术会导致类似人类的椎体滑脱。该模型可能有助于进一步开展关于滑脱椎间盘变化的实验研究。
