Klein S C, Kube D, Abts H, Diehl V, Tesch H
Medizinische Klinik I der Universität zu Köln, Germany.
Leuk Res. 1996 Aug;20(8):633-6. doi: 10.1016/0145-2126(96)00029-x.
Burkitt's lymphoma (BL) represents a high malignant B cell tumour. It has been proposed that cytokines are responsible for some of the characteristics of BL. We have analysed a panel of different BL and lymphoblastoid cell lines (LCLs) for the expression of cytokines, including: IL 1 alpha, IL 1 beta, IL2, IL3, IL4, IL6, IL8, IL10, TNF alpha and TNF beta and for the soluble cytokine receptor for IL2 (slL2R). Our results show that expression of IL8, IL10, TNF alpha or TNF beta was detected frequently in several of the Burkitt or lymphoblastoid cell lines. There was a correlation between Epstein-Barr virus (EBV) infection and cytokine protein production. Our results suggest that EBV promote the expression of IL8, IL10, TNF alpha and TNF beta.
伯基特淋巴瘤(BL)是一种高度恶性的B细胞肿瘤。有人提出细胞因子是导致BL某些特征的原因。我们分析了一组不同的伯基特淋巴瘤和淋巴母细胞样细胞系(LCLs)中细胞因子的表达情况,包括:白细胞介素1α(IL 1α)、白细胞介素1β(IL 1β)、白细胞介素2(IL2)、白细胞介素3(IL3)、白细胞介素4(IL4)、白细胞介素6(IL6)、白细胞介素8(IL8)、白细胞介素10(IL10)、肿瘤坏死因子α(TNFα)和肿瘤坏死因子β(TNFβ),以及白细胞介素2的可溶性细胞因子受体(slL2R)。我们的结果表明,在几种伯基特淋巴瘤或淋巴母细胞样细胞系中经常检测到IL8、IL10、TNFα或TNFβ的表达。爱泼斯坦-巴尔病毒(EBV)感染与细胞因子蛋白产生之间存在相关性。我们的结果表明,EBV促进IL8、IL10、TNFα和TNFβ的表达。