耐链霉素结核分枝杆菌分子耐药机制与表型耐药水平的相关性
Correlation of molecular resistance mechanisms and phenotypic resistance levels in streptomycin-resistant Mycobacterium tuberculosis.
作者信息
Meier A, Sander P, Schaper K J, Scholz M, Böttger E C
机构信息
Institut für Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Germany.
出版信息
Antimicrob Agents Chemother. 1996 Nov;40(11):2452-4. doi: 10.1128/AAC.40.11.2452.
Abstract
Quantitative susceptibility testing of clinical isolates of streptomycin-resistant Mycobacterium tuberculosis demonstrated that there is a close correlation between the molecular resistance mechanism and the in vitro activity of streptomycin: mutations in rpsL were mainly associated with high-level resistance, mutations in rrs were associated with an intermediate level of resistance, and streptomycin-resistant isolates with wild-type rpsL and rrs exhibited a low-level resistance phenotype. Investigations of streptomycin-resistant isolates with wild-type rpsL and rrs revealed that (i) there is no cross-resistance to other drugs and (ii) a permeability barrier may contribute to resistance, because resistance was significantly lowered in the presence of a membrane-active agent.
摘要
对耐链霉素结核分枝杆菌临床分离株进行的定量药敏试验表明，分子耐药机制与链霉素的体外活性之间存在密切相关性：rpsL基因突变主要与高水平耐药相关，rrs基因突变与中等水平耐药相关，而具有野生型rpsL和rrs的耐链霉素分离株表现出低水平耐药表型。对具有野生型rpsL和rrs的耐链霉素分离株的研究表明：（i）对其他药物无交叉耐药性；（ii）通透性屏障可能导致耐药，因为在存在膜活性剂的情况下耐药性显著降低。
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