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Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups.肠球菌-葡萄球菌IIIa型氨基糖苷3'-磷酸转移酶对氨基糖苷类抗生素的识别：底物氨基的作用
Antimicrob Agents Chemother. 1996 Nov;40(11):2648-50. doi: 10.1128/AAC.40.11.2648.
2
Regiospecificity of aminoglycoside phosphotransferase from Enterococci and Staphylococci (APH(3')-IIIa).来自肠球菌和葡萄球菌的氨基糖苷磷酸转移酶（APH(3')-IIIa）的区域特异性
Biochemistry. 1996 Jul 2;35(26):8686-95. doi: 10.1021/bi960389w.
3
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Mechanism of aminoglycoside 3'-phosphotransferase type IIIa: His188 is not a phosphate-accepting residue.IIIa型氨基糖苷3'-磷酸转移酶的作用机制：组氨酸188不是磷酸接受残基。
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Kinetic mechanism of aminoglycoside phosphotransferase type IIIa. Evidence for a Theorell-Chance mechanism.IIIa型氨基糖苷磷酸转移酶的动力学机制。支持Theorell-Chance机制的证据。
J Biol Chem. 1995 Oct 20;270(42):24686-92. doi: 10.1074/jbc.270.42.24686.
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Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases.氨基糖苷类抗生素耐药性所需的一种酶的结构揭示了其与真核蛋白激酶的同源性。
Cell. 1997 Jun 13;89(6):887-95. doi: 10.1016/s0092-8674(00)80274-3.
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Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study.氨基糖苷2″-磷酸转移酶IVa的氨基糖苷结合与催化特异性：一项热力学、结构和动力学研究
Biochim Biophys Acta. 2016 Apr;1860(4):802-13. doi: 10.1016/j.bbagen.2016.01.016. Epub 2016 Jan 21.

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Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry.通过靶点模拟实现氨基糖苷类抗生素耐药酶的底物混杂性
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Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.氨基糖苷类抗生素：作用机制、耐药性及应对耐药性策略的研究进展
Antimicrob Agents Chemother. 2000 Dec;44(12):3249-56. doi: 10.1128/AAC.44.12.3249-3256.2000.
4
Aminoglycosides: activity and resistance.氨基糖苷类：活性与耐药性。
Antimicrob Agents Chemother. 1999 Apr;43(4):727-37. doi: 10.1128/AAC.43.4.727.

本文引用的文献

1
Regiospecificity of aminoglycoside phosphotransferase from Enterococci and Staphylococci (APH(3')-IIIa).来自肠球菌和葡萄球菌的氨基糖苷磷酸转移酶（APH(3')-IIIa）的区域特异性
Biochemistry. 1996 Jul 2;35(26):8686-95. doi: 10.1021/bi960389w.
2
Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.氨基糖苷类耐药基因的分子遗传学及氨基糖苷类修饰酶的家族关系。
Microbiol Rev. 1993 Mar;57(1):138-63. doi: 10.1128/mr.57.1.138-163.1993.
3
Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: overexpression, purification, and substrate specificity.来自肠球菌的III型广谱氨基糖苷磷酸转移酶：过表达、纯化及底物特异性
Biochemistry. 1994 Jun 7;33(22):6936-44. doi: 10.1021/bi00188a024.
4
Purification and characterization of aminoglycoside 3'-phosphotransferase type IIa and kinetic comparison with a new mutant enzyme.IIa型氨基糖苷3'-磷酸转移酶的纯化与特性分析以及与一种新突变酶的动力学比较。
Antimicrob Agents Chemother. 1994 Apr;38(4):641-7. doi: 10.1128/AAC.38.4.641.
5
Kinetic mechanism of aminoglycoside phosphotransferase type IIIa. Evidence for a Theorell-Chance mechanism.IIIa型氨基糖苷磷酸转移酶的动力学机制。支持Theorell-Chance机制的证据。
J Biol Chem. 1995 Oct 20;270(42):24686-92. doi: 10.1074/jbc.270.42.24686.
6
Purification, characterization, and investigation of the mechanism of aminoglycoside 3'-phosphotransferase type Ia.Ia型氨基糖苷3'-磷酸转移酶的纯化、特性鉴定及作用机制研究
Biochemistry. 1995 Oct 3;34(39):12681-8. doi: 10.1021/bi00039a026.
7
Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III.粪肠球菌质粒基因的核苷酸序列，该基因编码III型3'5"-氨基糖苷磷酸转移酶
Gene. 1983 Sep;23(3):331-41. doi: 10.1016/0378-1119(83)90022-7.
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Penicillin-tobramycin synergism against enterococci: a comparison with penicillin and gentamicin.青霉素与妥布霉素对肠球菌的协同作用：与青霉素和庆大霉素的比较。
Antimicrob Agents Chemother. 1973 Apr;3(4):526-9. doi: 10.1128/AAC.3.4.526.
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The life and times of the Enterococcus.肠球菌的生存与时代
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The aminoglycosides.
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肠球菌-葡萄球菌IIIa型氨基糖苷3'-磷酸转移酶对氨基糖苷类抗生素的识别：底物氨基的作用

Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups.

作者信息

McKay G A, Roestamadji J, Mobashery S, Wright G D

机构信息

Department of Biochemistry, McMaster University, Hamilton, Ontario.

出版信息

Antimicrob Agents Chemother. 1996 Nov;40(11):2648-50. doi: 10.1128/AAC.40.11.2648.

DOI:10.1128/AAC.40.11.2648
PMID:8913482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163593/
Abstract

The interactions of the aminoglycoside 3'-phosphotransferase IIIa with aminoglycoside antibiotics lacking specific amino groups were examined by steady-state kinetic analyses. The results demonstrate that an amino group on C-1 and either an amino or a hydroxyl group at the 2' and 6' positions are important for detoxification of aminoglycosides by this enzyme.

摘要

通过稳态动力学分析研究了氨基糖苷3'-磷酸转移酶IIIa与缺乏特定氨基的氨基糖苷类抗生素之间的相互作用。结果表明，C-1位上的氨基以及2'和6'位上的氨基或羟基对于该酶使氨基糖苷类解毒很重要。