肠球菌-葡萄球菌IIIa型氨基糖苷3'-磷酸转移酶对氨基糖苷类抗生素的识别：底物氨基的作用
Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups.
作者信息
McKay G A, Roestamadji J, Mobashery S, Wright G D
机构信息
Department of Biochemistry, McMaster University, Hamilton, Ontario.
出版信息
Antimicrob Agents Chemother. 1996 Nov;40(11):2648-50. doi: 10.1128/AAC.40.11.2648.
Abstract
The interactions of the aminoglycoside 3'-phosphotransferase IIIa with aminoglycoside antibiotics lacking specific amino groups were examined by steady-state kinetic analyses. The results demonstrate that an amino group on C-1 and either an amino or a hydroxyl group at the 2' and 6' positions are important for detoxification of aminoglycosides by this enzyme.
摘要
通过稳态动力学分析研究了氨基糖苷3'-磷酸转移酶IIIa与缺乏特定氨基的氨基糖苷类抗生素之间的相互作用。结果表明，C-1位上的氨基以及2'和6'位上的氨基或羟基对于该酶使氨基糖苷类解毒很重要。
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