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1
Penicillin-tobramycin synergism against enterococci: a comparison with penicillin and gentamicin.青霉素与妥布霉素对肠球菌的协同作用：与青霉素和庆大霉素的比较。
Antimicrob Agents Chemother. 1973 Apr;3(4):526-9. doi: 10.1128/AAC.3.4.526.
2
Interaction of cefotaxime and aminoglycosides against enterococci in vitro.头孢噻肟与氨基糖苷类药物对肠球菌的体外相互作用。
Antimicrob Agents Chemother. 1983 Dec;24(6):847-50. doi: 10.1128/AAC.24.6.847.
3
Methodological variation in antibiotic synergy tests against enterococci.针对肠球菌的抗生素协同试验中的方法学差异。
J Clin Microbiol. 1981 Jan;13(1):73-5. doi: 10.1128/jcm.13.1.73-75.1981.
4
Synergism between N-formimidoyl thienamycin and gentamicin or tobramycin against enterococci.N-甲酰亚胺基硫霉素与庆大霉素或妥布霉素对肠球菌的协同作用。
Antimicrob Agents Chemother. 1982 Dec;22(6):1082-3. doi: 10.1128/AAC.22.6.1082.
5
Aminoglycoside-resistant enterococci.耐氨基糖苷类肠球菌
J Clin Pathol. 1977 Apr;30(4):375-80. doi: 10.1136/jcp.30.4.375.
6
Species-specific resistance to antimocrobial synergism in Streptococcus faecium and Streptococcus faecalis.粪肠球菌和屎肠球菌对抗菌协同作用的种属特异性抗性
J Infect Dis. 1979 Aug;140(2):203-8. doi: 10.1093/infdis/140.2.203.
7
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8
Comparative in vitro activity of nafcillin, oxacillin, and methicillin in combination with gentamicin and tobramycin against enterococci.萘夫西林、苯唑西林和甲氧西林联合庆大霉素及妥布霉素对肠球菌的体外比较活性
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9
Bactericidal activity of netilmicin compared with gentamicin and streptomycin, alone and in combination with penicillin, against penicillin tolerant viridans streptococci and enterococci.奈替米星与庆大霉素和链霉素单独及联合青霉素对耐青霉素的草绿色链球菌和肠球菌的杀菌活性比较
J Antimicrob Chemother. 1986 Oct;18(4):479-90. doi: 10.1093/jac/18.4.479.
10
High-level resistance to gentamicin in clinical isolates of enterococci.肠球菌临床分离株对庆大霉素的高水平耐药性。
J Infect Dis. 1983 Apr;147(4):751-7. doi: 10.1093/infdis/147.4.751.

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1
Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium.粪肠球菌染色体氨基糖苷6'-N-乙酰基转移酶的过表达及特性分析
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2
Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups.肠球菌-葡萄球菌IIIa型氨基糖苷3'-磷酸转移酶对氨基糖苷类抗生素的识别：底物氨基的作用
Antimicrob Agents Chemother. 1996 Nov;40(11):2648-50. doi: 10.1128/AAC.40.11.2648.
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Synergism between N-formimidoyl thienamycin and gentamicin or tobramycin against enterococci.N-甲酰亚胺基硫霉素与庆大霉素或妥布霉素对肠球菌的协同作用。
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4
Enterococcal bacteremia: clinical implications and determinants of death.肠球菌菌血症：临床意义及死亡的决定因素
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5
Methodological variation in antibiotic synergy tests against enterococci.针对肠球菌的抗生素协同试验中的方法学差异。
J Clin Microbiol. 1981 Jan;13(1):73-5. doi: 10.1128/jcm.13.1.73-75.1981.
6
Resistance to antibiotic synergism in Streptococcus faecalis: further studies with amikacin and with a new amikacin derivative, 4'-deoxy, 6'-N-methylamikacin.粪肠球菌对抗生素协同作用的耐药性：用阿米卡星和一种新的阿米卡星衍生物4'-脱氧、6'-N-甲基阿米卡星进行的进一步研究
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7
Synergism of carbenicillin and gentamicin against enterococci.羧苄青霉素与庆大霉素对肠球菌的协同作用。
Antimicrob Agents Chemother. 1973 Nov;4(5):564-8. doi: 10.1128/AAC.4.5.564.
8
Clinical study of the use of the new aminoglycoside tobramycin for therapy of infections due to gram-negative bacteria.新型氨基糖苷类药物妥布霉素用于治疗革兰氏阴性菌感染的临床研究。
Antimicrob Agents Chemother. 1974 Jan;5(1):75-81. doi: 10.1128/AAC.5.1.75.
9
High-content aminoglycoside disks for determining aminoglycoside-penicillin synergy against Enterococcus faecalis.用于确定氨基糖苷类药物与青霉素对粪肠球菌协同作用的高含量氨基糖苷类药敏纸片
J Clin Microbiol. 1988 Feb;26(2):257-60. doi: 10.1128/jcm.26.2.257-260.1988.
10
Effects of medium and inoculum variations on screening for high-level aminoglycoside resistance in Enterococcus faecalis.培养基和接种物变化对粪肠球菌高水平氨基糖苷类耐药性筛选的影响
J Clin Microbiol. 1988 Feb;26(2):250-6. doi: 10.1128/jcm.26.2.250-256.1988.

本文引用的文献

1
Use of autoclaved extracts of hemolytic streptococci for serological grouping.使用溶血性链球菌的高压灭菌提取物进行血清学分型。
Stanford Med Bull. 1955 May;13(2):290-1.
2
THE GROUP D STREPTOCOCCI.D群链球菌
Bacteriol Rev. 1964 Sep;28(3):330-66. doi: 10.1128/br.28.3.330-366.1964.
3
Structure of nebramycin factor 6, a new aminoglycosidic antibiotic.新氨基糖苷类抗生素暗霉素因子6的结构
Antimicrob Agents Chemother (Bethesda). 1970;10:309-13.
4
Prevalence of high-level resistance to aminoglycosides in clinical isolates of enterococci.肠球菌临床分离株中对氨基糖苷类高水平耐药的发生率。
Antimicrob Agents Chemother (Bethesda). 1970;10:335-40.
5
Preliminary studies with nebramycin factor 6.对新霉素因子6的初步研究。
Antimicrob Agents Chemother (Bethesda). 1970;10:314-21.
6
Enterococcal endocarditis. An analysis of 38 patients observed at the New York Hospital-Cornell Medical Center.肠球菌性心内膜炎。对纽约医院-康奈尔医学中心观察的38例患者的分析。
Arch Intern Med. 1970 Feb;125(2):258-64. doi: 10.1001/archinte.125.2.258.
7
Penicillin combined with gentamicin or streptomycin: synergism against enterococci.青霉素与庆大霉素或链霉素联合使用：对肠球菌有协同作用。
J Infect Dis. 1971 Dec;124(6):581-6. doi: 10.1093/infdis/124.6.581.
8
Synergy of penicillin and gentamicin against Enterococci.青霉素与庆大霉素对肠球菌的协同作用。
J Infect Dis. 1971 Dec;124 Suppl:S207-9. doi: 10.1093/infdis/124.supplement_1.s207.
9
Studies on antibiotic synergism against enterococci. I. Bacteriologic studies.抗肠球菌抗生素协同作用的研究。I. 细菌学研究。
J Lab Clin Med. 1971 May;77(5):821-8.
10
Mechanism of resistance to antibiotic synergism in enterococci.肠球菌对抗生素协同作用的耐药机制。
J Bacteriol. 1971 Mar;105(3):873-9. doi: 10.1128/jb.105.3.873-879.1971.

青霉素与妥布霉素对肠球菌的协同作用：与青霉素和庆大霉素的比较。

Penicillin-tobramycin synergism against enterococci: a comparison with penicillin and gentamicin.

作者信息

Moellering R C, Wennersten C, Weinstein A J

出版信息

Antimicrob Agents Chemother. 1973 Apr;3(4):526-9. doi: 10.1128/AAC.3.4.526.

DOI:10.1128/AAC.3.4.526
PMID:4208292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444447/
Abstract

Combinations of penicillin plus tobramycin have been compared with penicillin plus gentamicin against 27 strains of enterococci isolated from blood cultures. Penicillin plus gentamicin was synergistic against all strains. The combination of penicillin plus tobramycin was equally effective against strains of Streptococcus facalis, but was ineffective against all four strains of S. faecium tested.

摘要

已将青霉素加妥布霉素的联合用药与青霉素加庆大霉素的联合用药针对从血培养中分离出的27株肠球菌进行了比较。青霉素加庆大霉素对所有菌株均具有协同作用。青霉素加妥布霉素的联合用药对粪链球菌菌株同样有效，但对所测试的所有4株屎肠球菌均无效。