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Inhibition of the multidrug transporter NorA prevents emergence of norfloxacin resistance in Staphylococcus aureus.

作者信息

Markham P N, Neyfakh A A

出版信息

Antimicrob Agents Chemother. 1996 Nov;40(11):2673-4. doi: 10.1128/AAC.40.11.2673.

DOI:10.1128/AAC.40.11.2673
PMID:8913490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163601/
Abstract
摘要

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Inhibition of the multidrug transporter NorA prevents emergence of norfloxacin resistance in Staphylococcus aureus.多药转运蛋白NorA的抑制可防止金黄色葡萄球菌中诺氟沙星耐药性的出现。
Antimicrob Agents Chemother. 1996 Nov;40(11):2673-4. doi: 10.1128/AAC.40.11.2673.
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The effects of NorA inhibition on the activities of levofloxacin, ciprofloxacin and norfloxacin against two genetically related strains of Staphylococcus aureus in an in-vitro infection model.在体外感染模型中，NorA抑制对左氧氟沙星、环丙沙星和诺氟沙星针对两种基因相关金黄色葡萄球菌菌株活性的影响。
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Relationship between mutations in the coding and promoter regions of the norA genes in 42 unrelated clinical isolates of Staphylococcus aureus and the MICs of norfloxacin for these strains.
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Effects of NorA inhibitors on in vitro antibacterial activities and postantibiotic effects of levofloxacin, ciprofloxacin, and norfloxacin in genetically related strains of Staphylococcus aureus.诺氟沙星抑制剂对金黄色葡萄球菌基因相关菌株中左氧氟沙星、环丙沙星和诺氟沙星的体外抗菌活性及抗生素后效应的影响。
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Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.金黄色葡萄球菌NorA多药转运蛋白的多种新型抑制剂
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Inducible NorA-mediated multidrug resistance in Staphylococcus aureus.金黄色葡萄球菌中诱导型NorA介导的多重耐药性。
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Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.金黄色葡萄球菌的氟喹诺酮抗性蛋白NorA是一种多药外排转运蛋白。
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Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome.由norA介导的喹诺酮耐药性：生理学特征及其与flqB的关系，flqB是金黄色葡萄球菌染色体上的一个喹诺酮耐药位点。
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