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1
Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.金黄色葡萄球菌的氟喹诺酮抗性蛋白NorA是一种多药外排转运蛋白。
Antimicrob Agents Chemother. 1993 Jan;37(1):128-9. doi: 10.1128/AAC.37.1.128.
2
The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.枯草芽孢杆菌的多药外排转运蛋白是金黄色葡萄球菌NorA蛋白的结构和功能同源物。
Antimicrob Agents Chemother. 1992 Feb;36(2):484-5. doi: 10.1128/AAC.36.2.484.
3
Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.金黄色葡萄球菌NorA多药转运蛋白的多种新型抑制剂
Antimicrob Agents Chemother. 1999 Oct;43(10):2404-8. doi: 10.1128/AAC.43.10.2404.
4
Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus.金黄色葡萄球菌中由外排介导的氟喹诺酮耐药性。
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5
Evidence for the existence of a multidrug efflux transporter distinct from NorA in Staphylococcus aureus.金黄色葡萄球菌中存在一种不同于NorA的多药外排转运蛋白的证据。
Antimicrob Agents Chemother. 2000 May;44(5):1404-6. doi: 10.1128/AAC.44.5.1404-1406.2000.
6
Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome.由norA介导的喹诺酮耐药性：生理学特征及其与flqB的关系，flqB是金黄色葡萄球菌染色体上的一个喹诺酮耐药位点。
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The effects of NorA inhibition on the activities of levofloxacin, ciprofloxacin and norfloxacin against two genetically related strains of Staphylococcus aureus in an in-vitro infection model.在体外感染模型中，NorA抑制对左氧氟沙星、环丙沙星和诺氟沙星针对两种基因相关金黄色葡萄球菌菌株活性的影响。
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Effects of NorA inhibitors on in vitro antibacterial activities and postantibiotic effects of levofloxacin, ciprofloxacin, and norfloxacin in genetically related strains of Staphylococcus aureus.诺氟沙星抑制剂对金黄色葡萄球菌基因相关菌株中左氧氟沙星、环丙沙星和诺氟沙星的体外抗菌活性及抗生素后效应的影响。
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Efflux pump-mediated quinolone resistance in Staphylococcus aureus strains wild type for gyrA, gyrB, grlA, and norA.在金黄色葡萄球菌菌株中，外排泵介导的对喹诺酮类药物的耐药性，这些菌株的gyrA、gyrB、grlA和norA为野生型。
Antimicrob Agents Chemother. 1999 Feb;43(2):354-6. doi: 10.1128/AAC.43.2.354.

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Thymoquinone' potent impairment of multidrug-resistant Staphylococcus aureus NorA efflux pump activity.百里醌对耐甲氧西林金黄色葡萄球菌 NorA 外排泵活性的强烈抑制作用。
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Fighting Antimicrobial Resistance: Insights on How the NorA Efflux Pump Recognizes 2-Phenylquinoline Inhibitors by Supervised Molecular Dynamics (SuMD) and Molecular Docking Simulations.抗击抗微生物药物耐药性：通过监督分子动力学（SuMD）和分子对接模拟研究 NorA 外排泵识别 2-苯基喹啉抑制剂的见解。
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本文引用的文献

1
Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.金黄色葡萄球菌norA基因的核苷酸序列及特性，该基因赋予对喹诺酮类药物的抗性。
J Bacteriol. 1990 Dec;172(12):6942-9. doi: 10.1128/jb.172.12.6942-6949.1990.
2
A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus.norA基因中的点突变是金黄色葡萄球菌对喹诺酮耐药的原因。
Biochem Biophys Res Commun. 1990 Nov 15;172(3):1028-34. doi: 10.1016/0006-291x(90)91549-8.
3
Mechanisms of fluoroquinolone resistance in Staphylococcus aureus.金黄色葡萄球菌中氟喹诺酮耐药机制
J Infect Dis. 1991 May;163(5):1080-6. doi: 10.1093/infdis/163.5.1080.
4
Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.枯草芽孢杆菌中由外排介导的多药耐药性：与哺乳动物系统的异同
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4781-5. doi: 10.1073/pnas.88.11.4781.
5
The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.枯草芽孢杆菌的多药外排转运蛋白是金黄色葡萄球菌NorA蛋白的结构和功能同源物。
Antimicrob Agents Chemother. 1992 Feb;36(2):484-5. doi: 10.1128/AAC.36.2.484.

金黄色葡萄球菌的氟喹诺酮抗性蛋白NorA是一种多药外排转运蛋白。

Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.

作者信息

Neyfakh A A, Borsch C M, Kaatz G W

机构信息

Department of Medicinal Chemistry and Pharmacognosy (M/C 781), University of Illinois, Chicago 60680.

出版信息

Antimicrob Agents Chemother. 1993 Jan;37(1):128-9. doi: 10.1128/AAC.37.1.128.

DOI:10.1128/AAC.37.1.128
PMID:8431010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187619/
Abstract

The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.

摘要

金黄色葡萄球菌氟喹诺酮外排转运蛋白NorA的基因在枯草芽孢杆菌中表达时，可使枯草芽孢杆菌对多种结构不同的药物产生耐药性，而不仅仅是对氟喹诺酮类药物。NorA赋予枯草芽孢杆菌对相同药物的耐药性，其程度与枯草芽孢杆菌多药转运蛋白Bmr相似。NorA和Bmr的序列相似性为44%。利血平可完全逆转NorA和Bmr所赋予的耐药性。