金黄色葡萄球菌的氟喹诺酮抗性蛋白NorA是一种多药外排转运蛋白。
Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.
作者信息
Neyfakh A A, Borsch C M, Kaatz G W
机构信息
Department of Medicinal Chemistry and Pharmacognosy (M/C 781), University of Illinois, Chicago 60680.
出版信息
Antimicrob Agents Chemother. 1993 Jan;37(1):128-9. doi: 10.1128/AAC.37.1.128.
Abstract
The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.
摘要
金黄色葡萄球菌氟喹诺酮外排转运蛋白NorA的基因在枯草芽孢杆菌中表达时，可使枯草芽孢杆菌对多种结构不同的药物产生耐药性，而不仅仅是对氟喹诺酮类药物。NorA赋予枯草芽孢杆菌对相同药物的耐药性，其程度与枯草芽孢杆菌多药转运蛋白Bmr相似。NorA和Bmr的序列相似性为44%。利血平可完全逆转NorA和Bmr所赋予的耐药性。
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本文引用的文献
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Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.金黄色葡萄球菌norA基因的核苷酸序列及特性，该基因赋予对喹诺酮类药物的抗性。
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A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus.norA基因中的点突变是金黄色葡萄球菌对喹诺酮耐药的原因。
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Mechanisms of fluoroquinolone resistance in Staphylococcus aureus.金黄色葡萄球菌中氟喹诺酮耐药机制
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Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.枯草芽孢杆菌中由外排介导的多药耐药性：与哺乳动物系统的异同
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The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.枯草芽孢杆菌的多药外排转运蛋白是金黄色葡萄球菌NorA蛋白的结构和功能同源物。
Antimicrob Agents Chemother. 1992 Feb;36(2):484-5. doi: 10.1128/AAC.36.2.484.
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