模拟海马神经元树突中动作电位的衰减和衰竭。
Modeling the attenuation and failure of action potentials in the dendrites of hippocampal neurons.
作者信息
Migliore M
机构信息
National Research Council, Institute for Interdisciplinary Applications of Physics, Palermo, Italy.
出版信息
Biophys J. 1996 Nov;71(5):2394-403. doi: 10.1016/S0006-3495(96)79433-X.
Abstract
We modeled two different mechanisms, a shunting conductance and a slow sodium inactivation, to test whether they could modulate the active propagation of a train of action potentials in a dendritic tree. Computer simulations, using a compartmental model of a pyramidal neuron, suggest that each of these two mechanisms could account for the activity-dependent attenuation and failure of the action potentials in the dendrites during the train. Each mechanism is shown to be in good qualitative agreement with experimental findings on somatic or dendritic stimulation and on the effects of hyperpolarization. The conditions under which branch point failures can be observed, and a few experimentally testable predictions, are presented and discussed.
摘要
我们模拟了两种不同的机制，即分流电导和缓慢的钠失活，以测试它们是否能够调节树突状树突中一系列动作电位的主动传播。使用锥体神经元的房室模型进行的计算机模拟表明，这两种机制中的每一种都可以解释在一系列动作电位期间树突中动作电位的活动依赖性衰减和失败。结果表明，每种机制在定性上都与关于体细胞或树突刺激以及超极化效应的实验结果高度一致。本文提出并讨论了可以观察到分支点失败的条件以及一些可通过实验验证的预测。
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