Goerz G, Ippen H
Dtsch Med Wochenschr. 1977 Jul 22;102(29):1051-5. doi: 10.1055/s-0028-1105462.
39 patients were treated with carotinoids (beta-carotene alone or combined with canthaxanthine) with an oral dose of 50-150 mg/d, some of them for a period of several years. 23 of these were patients with porphyria (erythropoietic protoporphyria [EPP] 20, congenital erythropoietic porphyria 2, erythropoietic coproporphyria 1); 16 patients were suffering from various photodermatoses (solar urticaria 6, actinic reticuloid 5, UV-A intolerance 1, unclassified photodermatoses 4). Tolerance of the carotinoids was very good; no side effects were seen except for a yellow discoloration of the skin. In 19 of 20 EPP patients the result of the treatment was good, whereas no improvement was seen in the other kinds of porphyria. Of the 16 cases of photodermatoses not caused by porphyrinopathy, 6 responded to the therapy (solar urticaria 2, actinic reticuloid 2, UV-A intolerance 1, unclassified photodermatosis 1). Some cases showed great improvement as a result of the treatment.
39例患者接受类胡萝卜素治疗（单独使用β-胡萝卜素或与角黄素联合使用），口服剂量为50 - 150毫克/天，其中一些患者持续用药数年。其中23例为卟啉病患者（红细胞生成性原卟啉病[EPP]20例、先天性红细胞生成性卟啉病2例、红细胞生成性粪卟啉病1例）；16例患者患有各种光皮肤病（日光性荨麻疹6例、光化性类网状细胞增生症5例、紫外线A不耐受1例、未分类的光皮肤病4例）。类胡萝卜素的耐受性非常好；除皮肤发黄外，未观察到副作用。在20例EPP患者中，19例治疗效果良好，而其他类型的卟啉病未见改善。在16例非卟啉病引起的光皮肤病病例中，6例对治疗有反应（日光性荨麻疹2例、光化性类网状细胞增生症2例、紫外线A不耐受1例、未分类的光皮肤病1例）。一些病例经治疗后有很大改善。
