Wennersten G
Acta Derm Venereol. 1980;60(3):251-5.
Long-term treatment with oral carotenoids in 57 patients suffering from a variety of photodermatoses and disorders associated with cutaneous light sensitivity was evaluated. All patients were treated for two or more 6-month periods in separate years. Best therapeutic results were seen in PMLE patients, a good to excellent therapeutic response was noted for 65% of all patients, increasing to 81% of those assigned to skin types III and IV, and decreasing to 47% of those with skin types I and II. The therapeutic effect observed in disorders characterized by other mechanisms than provocation by solar radiation per se was less conspicuous, viz. for light-sensitive psoriasis and lupus erythematosus. Even here, therapeutic failure seems to be more common in individuals with skin types I and II than for skin types III and IV. Photodermatoses such as persistent light reaction, actinic reticuloid and solar urticaria did not respond to any significant degree to carotenoid treatment. Our findings would appear to justify further treatment with oral carotenoids in selected cases of PMLE, and a higher dosage level may be tried for non-responding individuals with light-sensitive psoriasis and DLE or SLE. Serious side effects have not been observed in spite of long-term therapy lasting several years.
对57例患有各种光皮肤病以及与皮肤光敏感相关疾病的患者进行了口服类胡萝卜素的长期治疗评估。所有患者在不同年份接受了两个或更多个为期6个月的治疗周期。在多形性日光疹（PMLE）患者中观察到最佳治疗效果，所有患者中有65%获得了良好至优异的治疗反应，在皮肤III型和IV型患者中这一比例增至81%，而在皮肤I型和II型患者中降至47%。在以除太阳辐射本身激发以外的其他机制为特征的疾病中观察到的治疗效果不太明显，即对于光敏性银屑病和红斑狼疮。即便如此，皮肤I型和II型个体的治疗失败似乎比皮肤III型和IV型个体更常见。持久性光反应、光化性类网状细胞增多症和日光性荨麻疹等光皮肤病对类胡萝卜素治疗没有任何显著反应。我们的研究结果似乎表明，在某些多形性日光疹病例中进一步使用口服类胡萝卜素治疗是合理的，对于对治疗无反应的光敏性银屑病、盘状红斑狼疮（DLE）或系统性红斑狼疮（SLE）患者，可以尝试更高的剂量水平。尽管进行了长达数年的长期治疗，但尚未观察到严重的副作用。
