Wiener P
Department of Biological Sciences, University of Warwick, Coventry, U.K.
Proc Biol Sci. 1996 Oct 22;263(1375):1283-9. doi: 10.1098/rspb.1996.0188.
Hypotheses have been put forward suggesting that immune selection generates much of the intra-patient genetic diversity of rapidly evolving viruses. A Monte Carlo simulation is presented which models sequence evolution in an HIV-like virus under selection from the immune system. Measurements of evolutionary change are then made from the resulting sequences, generating predicted outcomes for each scenario. Frequency dependent immune selection is shown by two statistical measurements to have a significant effect on viral sequence evolution. The use of drawing inferences about underlying evolutionary processes from samples of viral diversity in infected individuals is discussed.
已经有人提出假说，认为免疫选择产生了快速进化病毒在患者体内的大部分遗传多样性。本文提出了一个蒙特卡罗模拟，该模拟对一种类似HIV的病毒在免疫系统选择下的序列进化进行建模。然后从所得序列中进行进化变化的测量，为每种情况生成预测结果。通过两项统计测量表明，频率依赖性免疫选择对病毒序列进化有显著影响。本文还讨论了利用感染个体中病毒多样性样本推断潜在进化过程的问题。
