Yoshimoto H, Tamura M
Department of Ophthalmology, Hirosaki University School of Medicine.
Nihon Rinsho. 1996 Oct;54(10):2786-9.
Impaired glucose tolerance (IGT) has been one of the risk factors of Branch Retinal Vein Obstruction (BRVO). In order to study the contribution of IGT to the pathogenesis of BRVO, the 75 gram oral glucose tolerance test and immunoreactive insulin (IRI) measurement were investigated in 180 BRVO patients. IGT was found in 103 patients, and about 40% of these patients showed hyperinsulinemia and secondary insulin resistance. This result suggests that IGT with BRVO are in a state of hyperinsulinemia and hyperglycemia and hyperinsulinemia play an important role in thrombogenesis, such as injury to the venous endothelial cells.
糖耐量受损（IGT）一直是视网膜分支静脉阻塞（BRVO）的危险因素之一。为了研究IGT在BRVO发病机制中的作用，对180例BRVO患者进行了75克口服葡萄糖耐量试验和免疫反应性胰岛素（IRI）测定。103例患者存在IGT，其中约40%的患者表现为高胰岛素血症和继发性胰岛素抵抗。这一结果表明，BRVO合并IGT患者处于高胰岛素血症和高血糖状态，高胰岛素血症在血栓形成过程中发挥重要作用，如对静脉内皮细胞的损伤。
