Kawazu S, Tomono S
2nd Dept. Int. Medicine, Gunma Univ. Sch. Medicine.
Nihon Rinsho. 1996 Oct;54(10):2692-9.
Those who have IGT (impaired glucose tolerance) are thought to be highly risky to atherosclerotic coronary artery disease (CAD), probably because of the frequent association with insulin resistance or hyperinsulinemia, obesity or abdominal fat accumulation, hypertriglyceridemia and so on. Whether insulin resistance which is one of the major causes of IGT, following hyperglycemia itself or both is really responsible for CAD is remained to be clarified. Furthermore, IGT is also an apparent candidate for NIDDM in future. Thus, IGT should be intensively treated to prevent or delay the onset of NIDDM and also to minimize the adverse events by atherosclerotic CAD.
糖耐量受损（IGT）者被认为患动脉粥样硬化性冠心病（CAD）的风险很高，这可能是因为他们经常伴有胰岛素抵抗或高胰岛素血症、肥胖或腹部脂肪堆积、高甘油三酯血症等。作为IGT主要病因之一的胰岛素抵抗，究竟是继高血糖之后还是两者共同导致CAD，仍有待阐明。此外，IGT未来显然也是非胰岛素依赖型糖尿病（NIDDM）的候选对象。因此，应积极治疗IGT，以预防或延缓NIDDM的发病，并尽量减少动脉粥样硬化性CAD带来的不良事件。
