Liang S, Ohtsuki Y, Iwata J, Furihata M, Ido E, Sonobe H
Department of Pathology, Kochi Medical School, Japan.
Acta Med Okayama. 1996 Oct;50(5):279-83. doi: 10.18926/AMO/30496.
Epithelioid hemangioendothelioma is a relatively rare lesion. Although its histogenesis has been well described, its immunohistochemical characteristics remain controversial. A case of epithelioid hemangioendothelioma of the soft tissue of the right leg in a 67-year-old Chinese woman is reported. Histologic findings of intracytoplasmic lumina in the tumor cells and positive immunostaining for vimentin, factor VIII-related antigen. CD34 and Ulex europaeus agglutinin 1 (UEA-1) were obtained, demonstrating differentiation of the tumor cells to endothelial cells, although staining for antibodies to cytokeratins AE1/AE3 and CAM5.2 was weak. CD34 as well as Factor VIII-related antigen is a useful marker of endothelial differentiation in this tumor. A review of the literature is also presented.
上皮样血管内皮瘤是一种相对罕见的病变。尽管其组织发生已得到充分描述，但其免疫组化特征仍存在争议。本文报道了一名67岁中国女性右下肢软组织上皮样血管内皮瘤的病例。肿瘤细胞内可见胞质内管腔，波形蛋白、因子VIII相关抗原、CD34和荆豆凝集素1（UEA-1）免疫染色阳性，提示肿瘤细胞向内皮细胞分化，不过细胞角蛋白AE1/AE3和CAM5.2抗体染色较弱。CD34以及因子VIII相关抗原是该肿瘤内皮分化的有用标志物。本文还对相关文献进行了综述。
