Hamazaki T, Sawazaki S, Asaoka E, Itomura M, Mizushima Y, Yazawa K, Kuwamori T, Kobayashi M
The First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
J Nutr. 1996 Nov;126(11):2784-9. doi: 10.1093/jn/126.11.2784.
Fish oils, purified eicosapentaenoic acid and docosahexaenoic acid (DHA) have been reported to improve blood lipid concentrations, especially those of triglycerides in humans. However, to our knowledge there have been no double-blind studies investigating the effects of DHA-rich fish oil on blood lipid concentrations. Therefore, we conducted a placebo-controlled double-blind study. Twenty-four healthy, normolipidemic young adults took either DHA-rich fish oil capsules containing 1.5-1.8 g of DHA or control oil capsules containing 97% soybean oil and 3% fish oil for 13 wk. Blood samples were taken at the start and end of the study, and serum lipids concentrations were compared. There were no significant changes over time in the DHA group in the following serum lipids: total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, lipoprotein(a), and apolipoproteins A1 and B. In contrast, apolipoprotein A1 concentrations slightly (10%) but significantly increased over time in the control group. Docosahexaenoic acid at a dose of less than 2 g/d did not change serum lipid concentrations of normolipidemic subjects. The effects of DHA in hyperlipidemic patients remain to be investigated in a double-blind study.
据报道，鱼油、纯化的二十碳五烯酸和二十二碳六烯酸（DHA）可改善人体血脂浓度，尤其是甘油三酯的浓度。然而，据我们所知，尚无双盲研究调查富含DHA的鱼油对血脂浓度的影响。因此，我们进行了一项安慰剂对照双盲研究。24名健康的血脂正常的年轻成年人服用了含有1.5 - 1.8克DHA的富含DHA的鱼油胶囊，或服用了含有97%大豆油和3%鱼油的对照油胶囊，为期13周。在研究开始和结束时采集血样，并比较血脂浓度。DHA组的以下血脂指标在研究期间无显著变化：总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、脂蛋白（a）以及载脂蛋白A1和B。相比之下，对照组的载脂蛋白A1浓度随时间略有（10%）但显著升高。剂量小于2克/天的DHA不会改变血脂正常受试者的血脂浓度。DHA对高脂血症患者的影响仍有待在双盲研究中进行调查。
