Aractingi S, Bakhos D, Flageul B, Vérola O, Brunet M, Dubertret L, Morinet F
Unite de Dermatologie, Hôpital Tenon, Paris, France.
Br J Dermatol. 1996 Oct;135(4):599-602.
The pathogenesis of viral exanthems remains unclear. We have undertaken an immunohistochemical study of lesional skin biopsies in patients with the papular-purpuric gloves and socks syndrome (PPGSS) secondary to parvovirus B19 infection. Intracytoplasmic staining of the dermal endothelial cells, keratinocytes, and sweat glands was shown with an antibody to parvovirus B19. There were perivascular dermal infiltrates with T cells, sometimes with exocytosis. By polymerase chain reaction, virus DNA was detected in all skin biopsies and in one serum sample. The cutaneous manifestations of parvovirus infection seem secondary to infection of the endothelium and epidermis.
病毒疹的发病机制仍不清楚。我们对细小病毒B19感染继发的丘疹紫癜性手套和袜套综合征（PPGSS）患者的皮损活检组织进行了免疫组织化学研究。用抗细小病毒B19抗体显示真皮内皮细胞、角质形成细胞和汗腺的胞浆内染色。真皮血管周围有T细胞浸润，有时伴有细胞外渗。通过聚合酶链反应，在所有皮肤活检组织和一份血清样本中检测到病毒DNA。细小病毒感染的皮肤表现似乎继发于内皮和表皮的感染。
