Muellegger R R, Schluepen E M, Millner M M, Soyer H P, Volkenandt M, Kerl H
Department of Dermatology, Karl Franzens University, Graz, Austria.
Br J Dermatol. 1996 Oct;135(4):609-12.
We report a case of acrodermatitis chronica atrophicans in an 11-year-old girl living in an area endemic for Lyme borreliosis. The diagnosis was first made on the basis of clinical, histopathological and serological findings. Moreover, Borrelia burgdorferi-specific DNA was amplified from lesional skin by polymerase chain reaction. Intravenous treatment with ceftriaxone (2 g once daily) for 2 weeks was initiated. The skin changes clearly responded to the therapy, and Borrelia burgdorferi-specific gene segments were no longer detectable by polymerase chain reaction. This is the first report of molecular-proven acrodermatitis chronica atrophicans in childhood. The occurrence of this late skin manifestation of Lyme borreliosis in children is reviewed.
我们报告了一例11岁女童的慢性萎缩性肢端皮炎病例，该女童居住在莱姆病流行地区。诊断首先基于临床、组织病理学和血清学检查结果。此外，通过聚合酶链反应从病变皮肤中扩增出伯氏疏螺旋体特异性DNA。开始静脉注射头孢曲松（每日1次，每次2 g），持续2周。皮肤病变对治疗有明显反应，聚合酶链反应检测不到伯氏疏螺旋体特异性基因片段。这是儿童期经分子证实的慢性萎缩性肢端皮炎的首例报告。本文对儿童莱姆病这种晚期皮肤表现的发生情况进行了综述。
