Rudberg U, Nylander B
Department of Diagnostic Radiology, St. Göran's Hospital, Stockholm, Sweden.
Acta Radiol. 1996 Sep;37(5):672-5. doi: 10.1177/02841851960373P250.
The purpose with this study was to investigate the usefulness of the 75SeHCAT test in patients suffering from "functional" diarrhoea and to disclose earlier radiological investigations performed in the course of disease.
Twenty patients with chronic diarrhoea of unknown cause were investigated with the 75SeHCAT test. The cholestyramine test and an estimation of oro-caecal transit time (OCTT) were also performed in 13 and 10 patients respectively.
Ten patients had low 7-day retention (< or = 15%). Nine of these were tested with cholestyramine and 8 showed complete relief from the diarrhoea. The cholestyramine test had no effect on the 4 patients with normal bile acid retention. No correlation was found between the retention of 75SeHCAT and OCCT. A total of 80 inconclusive gastrointestinal barium examinations were performed during the course of disease.
Pathological bile acid retention, studied with the radiological 75SeHCAT test, is common in patients with diarrhoea of unknown cause. The test should be performed earlier in the course of disease in order to prevent unnecessary radiological investigations and to reduce patient suffering and distress.
本研究旨在调查75硒-同型半胱氨酸-甘氨酸-牛磺酸（75SeHCAT）试验在“功能性”腹泻患者中的实用性，并披露疾病过程中早期进行的放射学检查。
对20例病因不明的慢性腹泻患者进行75SeHCAT试验。分别对13例和10例患者进行了消胆胺试验和口-盲肠转运时间（OCTT）评估。
10例患者7天潴留率低（≤15%）。其中9例接受了消胆胺试验，8例腹泻完全缓解。消胆胺试验对4例胆汁酸潴留正常的患者无效。75SeHCAT的潴留与OCCT之间未发现相关性。疾病过程中总共进行了80次不确定的胃肠道钡剂检查。
通过放射学75SeHCAT试验研究发现，病理性胆汁酸潴留在病因不明的腹泻患者中很常见。该试验应在疾病过程中尽早进行，以避免不必要的放射学检查，减轻患者的痛苦和困扰。
