β-激动剂治疗对大鼠组织和尿液中牛磺酸水平的影响。作用机制及保护意义。

Effect of treatment with beta-agonists on tissue and urinary taurine levels in rats. Mechanism and implications for protection.

作者信息

Waterfield C J, Carvalho F, Timbrell J A

机构信息

Department of Toxicology, School of Pharmacy, London, United Kingdom.

出版信息

Adv Exp Med Biol. 1996;403:233-45. doi: 10.1007/978-1-4899-0182-8_25.

DOI:10.1007/978-1-4899-0182-8_25

PMID:8915360

Abstract

Administration of clenbuterol to rats in the drinking water over a four day period increased incorporation of [3H]leucine into muscle protein but did not result in an increase in body or muscle weight. However, both urinary and liver taurine were significantly reduced at the highest dose of clenbuterol (2 mg.kg-1.day-1). Salbutamol also reduced urinary levels of taurine in both rats and humans. The reduction in the body pool of taurine caused by beta-agonists may be of concern as taurine has been shown to have protective properties.

摘要

在为期四天的时间里，给大鼠饮用含克伦特罗的水，可增加[3H]亮氨酸掺入肌肉蛋白，但不会导致体重或肌肉重量增加。然而，在克伦特罗最高剂量（2毫克·千克-1·天-1）时，尿牛磺酸和肝牛磺酸均显著降低。沙丁胺醇也会降低大鼠和人类尿液中的牛磺酸水平。β-激动剂导致体内牛磺酸池减少可能令人担忧，因为已证明牛磺酸具有保护特性。