Storms R F, Ferraro J A, Thedinger B S
Hearing and Speech Department, University of Kansas Medical Center, Kansas City, USA.
Am J Otol. 1996 Nov;17(6):874-82.
This study examined the relationship between objective changes in electrocochleographic (ECochG) parameters and subjective changes in symptoms in a group of patients with Menière's disease/endolymphatic hydrops (MD/ELH) after application of positive and negative atmospheric pressure changes to the sealed ear canal. Our goals were to further examine the therapeutic effects of atmospheric pressure change on the treatment of MD/ELH, as reported by a series of Swedish studies, and to examine the utility of ECochG for monitoring these effects. By combining a clinical immittance unit and an evoked potential unit, ECochG responses were obtained from the tympanic membrane while different atmospheric pressures were applied indirectly to the middle ear via the external ear canal. For comparison, ECochG responses at various atmospheric pressures also were obtained for otologically normal subjects. For the MD/ELH group, there was a significant (p < 0.01) reduction in the abnormal summating potential/action potential (SP/AP) amplitude ratio, although the amplitude ratios did not become "normal." There was no significant effect of ear canal pressure change on ECochG components for the normative subjects. Although these findings were encouraging regarding the therapeutic effects of overpressure, they were not accompanied with changes in MD/ELH symptoms.
本研究探讨了一组梅尼埃病/内淋巴积水（MD/ELH）患者在向密封耳道施加正负压变化后，耳蜗电图（ECochG）参数的客观变化与症状主观变化之间的关系。我们的目标是进一步研究如一系列瑞典研究所报道的，气压变化对MD/ELH治疗的效果，并研究ECochG在监测这些效果方面的效用。通过将临床声导抗仪和诱发电位仪相结合，在通过外耳道间接向中耳施加不同气压时，从鼓膜获取ECochG反应。作为对照，也对外耳正常的受试者在不同气压下进行了ECochG反应测试。对于MD/ELH组，异常总和电位/动作电位（SP/AP）振幅比有显著（p < 0.01）降低，尽管振幅比并未变为“正常”。耳道压力变化对正常受试者的ECochG成分无显著影响。尽管这些结果在超压治疗效果方面令人鼓舞，但并未伴随MD/ELH症状的改变。
