Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex.
作者信息
Fahnestock M, Scott S A, Jetté N, Weingartner J A, Crutcher K A
机构信息
Department of Biomedical Sciences, McMaster University, Hamilton, Ont., Canada.
出版信息
Brain Res Mol Brain Res. 1996 Nov;42(1):175-8. doi: 10.1016/s0169-328x(96)00193-3.
PMID:8915599
Abstract
Nerve growth factor (NGF) mRNA and protein levels were determined in parietal cortex samples from both normal and Alzheimer's disease (AD) patients. NGF protein levels were slightly elevated in AD patients compared to controls, but NGF mRNA levels were unchanged in the same tissue samples. Thus, small but reproducible increases in NGF protein reported in AD cortex do not result from increases in NGF mRNA.
摘要
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