阿仑膦酸钠对接受甲巯咪唑治疗的绝经前后甲状腺功能亢进女性骨质流失的影响。
Effects of alendronate on bone loss in pre- and postmenopausal hyperthyroid women treated with methimazole.
作者信息
Lupoli G, Nuzzo V, Di Carlo C, Affinito P, Vollery M, Vitale G, Cascone E, Arlotta F, Nappi C
机构信息
Department of Molecular and Clinical Endocrinology and Oncology, School of Medicine, University Federico II, Naples, Italy.
出版信息
Gynecol Endocrinol. 1996 Oct;10(5):343-8. doi: 10.3109/09513599609012821.
High levels of thyroid hormones accelerate bone turnover. The aim of the present study was to evaluate the effects of treatment with alendronate in patients affected by hyperthyroidism and osteoporosis. We studied 40 hyperthyroid patients with bone loss, divided into two groups according to menopausal state. Before treatment and after 6 and 12 months, serum thyroid hormones levels, serum osteocalcin level and bone mineral density were evaluated. In all patients we observed an increase in bone mineral density after treatment with alendronate, and a corresponding decrease in serum osteocalcin level.
高水平的甲状腺激素会加速骨转换。本研究的目的是评估阿仑膦酸钠治疗对甲状腺功能亢进症合并骨质疏松症患者的影响。我们研究了40例患有骨质流失的甲状腺功能亢进症患者，根据绝经状态分为两组。在治疗前以及治疗6个月和12个月后，评估血清甲状腺激素水平、血清骨钙素水平和骨密度。在所有患者中，我们观察到阿仑膦酸钠治疗后骨密度增加，血清骨钙素水平相应降低。
Zotero 插件