Department of Endocrinology & Metabolism, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
Indian J Med Res. 2012 Mar;135(3):277-86.
Thyrotoxicosis, a clinical syndrome characterized by manifestations of excess thyroid hormone, is one of the commonly-recognised conditions of the thyroid gland. Thyrotoxicosis causes acceleration of bone remodelling and though it is one of the known risk factors for osteoporosis, the metabolic effects of thyroxine on bone are not well discussed. Studies show that thyroid hormones have effects on bone, both in vitro and in vivo. Treatment of thyrotoxicosis leads to reversal of bone loss and metabolic alterations, and decreases the fracture risk. There are limited studies in India as to whether these changes are fully reversible. In this review we discuss about the effects of thyrotoxicosis (endogenous and exogenous) on bone and mineral metabolism, effects of subclinical thyrotoxicosis on bone and mineral metabolism and effects of various forms of treatment in improving the bone mineral density in thyrotoxicosis.
甲状腺功能亢进症，一种以甲状腺激素过度表现为特征的临床综合征，是甲状腺常见疾病之一。甲状腺功能亢进症导致骨重塑加速，尽管它是骨质疏松症的已知危险因素之一，但甲状腺素对骨的代谢作用尚未得到充分讨论。研究表明，甲状腺激素对骨具有体外和体内作用。甲状腺功能亢进症的治疗可逆转骨丢失和代谢改变，并降低骨折风险。印度关于这些变化是否完全可逆的研究有限。在这篇综述中，我们讨论了甲状腺功能亢进症（内源性和外源性）对骨和矿物质代谢的影响，亚临床甲状腺功能亢进症对骨和矿物质代谢的影响，以及各种治疗方法在改善甲状腺功能亢进症患者骨密度方面的作用。
