Maak B, Frenzel J
Eur J Pediatr. 1977 Aug 12;125(4):259-64. doi: 10.1007/BF00493570.
The correlation between the appearance of functionally-atypical factor VII and perinatal complications was investigated in 66 newborn infants. The presence of an abnormal clotting factor was assumed if the ratio between clotting activity and antigen-related factor VII material exceeded the normal range for adult plasma. The newborns were divided into a risk group of infants threatened by adverse conditions of labour or post-natal adaptation, and a control group of newborns without perinatal complications. The findings were as follows: The incidence of atypical factor VII was significantly higher in the risk group. There was no difference between prenatal and postnatal complications in this respect. Infants born by caesarian section or with cord complications, as well as those with delayed respiratory adaptation, showed a higher incidence of atypical factor VII than the risk group as a whole. Atypical factor VII was not detected until the third day of life, irrespective of the prenatal or postnatal complications. These findings suggest that perinatal risk factors are associated with an alteration of factor VII synthesis.
在66名新生儿中研究了功能异常的凝血因子VII的出现与围产期并发症之间的相关性。如果凝血活性与抗原相关的凝血因子VII物质之间的比率超过成人血浆的正常范围，则假定存在异常凝血因子。将新生儿分为受分娩或产后适应不良状况威胁的婴儿风险组和无围产期并发症的新生儿对照组。结果如下：风险组中异常凝血因子VII的发生率明显更高。在这方面，产前和产后并发症之间没有差异。剖宫产或有脐带并发症出生的婴儿，以及呼吸适应延迟的婴儿，其异常凝血因子VII的发生率高于整个风险组。无论产前或产后并发症如何，直到出生后第三天才检测到异常凝血因子VII。这些发现表明围产期危险因素与凝血因子VII合成的改变有关。
