Pomeroy S L, Zurakowski D, Khoxayo S, Endara M, Dikkes P
Department of Neurology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Comp Neurol. 1996 Nov 18;375(3):518-25. doi: 10.1002/(SICI)1096-9861(19961118)375:3<518::AID-CNE12>3.0.CO;2-H.
We have examined the postnatal development of satellite cells associated with parasympathetic neurons of mouse salivary duct ganglia. The number of satellite cells associated with each neuron was found to increase during the first 8 weeks after birth but remained constant thereafter. This corresponds to the period of maximal growth of the salivary gland that serves as the target organ innervated by these neurons. At all ages examined, the number of satellite cells associated with each neuron was found to be highly correlated with neuronal volume. The development of satellite cells associated with individual identified neurons was followed directly by in vivo video microscopy over several months, and the number of satellite cell nuclei was found to increase in regions of the neuronal surface with increasing numbers of synaptic boutons. These results indicate that the postnatal addition of satellite cells to parasympathetic neurons is linked to neuronal enlargement and that synaptic remodeling occurs in concert with satellite cell development.
我们研究了与小鼠唾液腺导管神经节副交感神经元相关的卫星细胞的出生后发育情况。发现与每个神经元相关的卫星细胞数量在出生后的前8周内增加，但此后保持恒定。这与作为这些神经元所支配的靶器官的唾液腺最大生长时期相对应。在所有检查的年龄段，发现与每个神经元相关的卫星细胞数量与神经元体积高度相关。通过体内视频显微镜直接观察了几个月内与单个已识别神经元相关的卫星细胞的发育情况，发现随着突触小体数量的增加，神经元表面区域的卫星细胞核数量也会增加。这些结果表明，副交感神经元出生后卫星细胞的添加与神经元的增大有关，并且突触重塑与卫星细胞的发育协同发生。
