16α-吉他洛辛及其16-乙酸酯与人血清白蛋白的结合
Binding of 16alpha-gitoxin and its 16-acetate to human serum albumin.
作者信息
Richter M, Haustein K O
出版信息
Eur J Clin Pharmacol. 1977 Jul 19;11(6):459-61. doi: 10.1007/BF00562939.
PMID:891591
Abstract
The binding of semi-synthetic (16alpha-gitoxin and its 16-acetate) and naturally occurring cardioactive glycosides (digitoxin, ouabain) to human serum albumin was studied using equilibrium dialysis, ultracentrifugation and gel filtration. 16alpha-gitoxin was 75% bound and its 16-acetate 95%. The percentage binding of digitoxin and ouabain was in good agreement with values reported in literature.
摘要
采用平衡透析、超速离心和凝胶过滤法研究了半合成（16α-吉托辛及其16-乙酸酯）和天然存在的强心苷（洋地黄毒苷、哇巴因）与人血清白蛋白的结合情况。16α-吉托辛的结合率为75%，其16-乙酸酯的结合率为95%。洋地黄毒苷和哇巴因的结合百分比与文献报道的值高度一致。
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