诺氟沙星-甘氨酸乙酸盐在两种不同温度下于牙鲆（ Paralichthys olivaceus）体内的比较药代动力学及组织分布

Comparative pharmacokinetics and tissue distribution of norfloxacin-glycine acetate in flounder, (Paralichthys olivaceus) at two different temperatures.

作者信息

Park S C, Yun H I, Oh T K

机构信息

Applied Microbiology Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Republic of Korea.

出版信息

J Vet Med Sci. 1996 Oct;58(10):1039-40. doi: 10.1292/jvms.58.10_1039.

DOI:10.1292/jvms.58.10_1039

PMID:8916010

Abstract

The pharmacokinetics of norfloxacin-glycine acetate (NFXGA), a newly formulated norfloxacin, was investigated in healthy flounders at two different seawater temperature (at 12 degrees C and 20 degrees C) varying concentrations (100 ppm and 10 ppm), using dipping administration. It was shown that the elimination half-life (T1/2) of norfloxacin at 20 degrees C (10 ppm: 13.95 +/- 1.18 hr, 100 ppm: 11.71 +/- 1.32 hr) was significantly shorter than that at 12 degrees C (10 ppm: 16.61 +/- 1.47 hr, 100 ppm: 16.32 +/- 1.19 hr) in flounders. Mean residence time (MRT) was calculated at 12 degrees C (10 ppm: 194.87 +/- 29.88 hr, 100 ppm: 1,222.37 +/- 161.45 hr) and 20 degrees C (10 ppm: 168.42 +/- 25.85, 100 ppm: 606.14 +/- 122.75 hr). Meanwhile, in the flounder tissue distribution of norfloxacin. It was shown that serum, muscle, kidney, and liver exhibited different elimination half-lives of norfloxacin.

摘要

采用浸浴给药方式，在两种不同海水温度（12℃和20℃）、两种不同浓度（100 ppm和10 ppm）条件下，对健康牙鲆新配方诺氟沙星-甘氨酸乙酸盐（NFXGA）的药代动力学进行了研究。结果表明，牙鲆在20℃时诺氟沙星的消除半衰期（T1/2）（10 ppm：13.95±1.18小时，100 ppm：11.71±1.32小时）明显短于12℃时（10 ppm：16.61±1.47小时，100 ppm：16.32±1.19小时）。在12℃（10 ppm：194.87±29.88小时，100 ppm：1222.37±161.45小时）和20℃（10 ppm：168.42±25.85，100 ppm：606.14±122.75小时）条件下计算了平均滞留时间（MRT）。同时，研究了牙鲆组织中诺氟沙星的分布情况。结果表明，血清、肌肉、肾脏和肝脏中诺氟沙星的消除半衰期各不相同。