Salsolinol对平滑肌对催产素和加压素反应的拮抗作用。

Antagonism of smooth muscle responses to oxytocin and vasopressin by salsolinol.

作者信息

Hamilton M G, Hirst M

出版信息

Eur J Pharmacol. 1977 Aug 1;44(3):279-81. doi: 10.1016/0014-2999(77)90075-9.

Abstract

The responses of isolated smooth muscle tissues to the polypeptides oxytocin, vasopressin and bradykinin were evaluated in the presence of the tetrahydroisoquinoline salsolinol. Significant antagonism occurred to oxytocin and vasopressin while the effects of bradykinin were unaltered. These results suggest that the in vivo formation of salsolinol after ethanol consumption could have significant physiological consequences.

摘要

在四氢异喹啉萨索林醇存在的情况下，评估了分离的平滑肌组织对多肽催产素、血管加压素和缓激肽的反应。对催产素和血管加压素出现了显著的拮抗作用，而缓激肽的作用未改变。这些结果表明，乙醇摄入后体内萨索林醇的形成可能会产生重大的生理后果。